IL18R1

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Interleukin 18 receptor 1
Identifiers
Symbols IL18R1 ; CD218a; CDw218a; IL-1Rrp; IL18RA; IL1RRP
External IDs OMIM604494 MGI105383 HomoloGene2861 GeneCards: IL18R1 Gene
RNA expression pattern
PBB GE IL18R1 206618 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8809 16182
Ensembl ENSG00000115604 ENSMUSG00000026070
UniProt Q13478 Q61098
RefSeq (mRNA) NM_001282399 NM_001161842
RefSeq (protein) NP_001269328 NP_001155314
Location (UCSC) Chr 2:
102.93 – 103.02 Mb
Chr 1:
40.47 – 40.5 Mb
PubMed search [1] [2]

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.[1] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.