C-C chemokine receptor type 6

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Chemokine (C-C motif) receptor 6
Identifiers
Symbols CCR6 ; BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196; CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22
External IDs OMIM601835 MGI1333797 HomoloGene3214 IUPHAR: CCR6 ChEMBL: 4423 GeneCards: CCR6 Gene
Orthologs
Species Human Mouse
Entrez 1235 12458
Ensembl ENSG00000112486 ENSMUSG00000040899
UniProt P51684 O54689
RefSeq (mRNA) NM_004367 NM_001190333
RefSeq (protein) NP_004358 NP_001177262
Location (UCSC) Chr 6:
167.53 – 167.55 Mb
Chr 17:
8.24 – 8.26 Mb
PubMed search [1] [2]

Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene.[1] CCR6 has also recently been designated CD196 (cluster of differentiation 196).

Function[edit]

This protein belongs to family A of G protein-coupled receptor superfamily. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.[2]

Molecular biology[edit]

The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids (molecular weight 42,494 Da).[1]

Clinical significance[edit]

CCR6 has been associated with Crohn's disease.[3] Expression of CCR6 was found to be up-regulated in colorectal cancer. Novel researches identified microRNA that is able to downregulate CCR6 in cancer cell lines. [4]

References[edit]

  1. ^ a b Zaballos A, Varona R, Gutiérrez J, Lind P, Márquez G (October 1996). "Molecular cloning and RNA expression of two new human chemokine receptor-like genes". Biochem. Biophys. Res. Commun. 227 (3): 846–53. doi:10.1006/bbrc.1996.1595. PMID 8886020. 
  2. ^ "Entrez Gene: CCR6 chemokine (C-C motif) receptor 6". 
  3. ^ Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, Sleiman PM, Imielinski M, Glessner J, Hou C, Wilson DC, Walters T, Kim C, Frackelton EC, Lionetti P, Barabino A, Van Limbergen J, Guthery S, Denson L, Piccoli D, Li M, Dubinsky M, Silverberg M, Griffiths A, Grant SF, Satsangi J, Baldassano R, Hakonarson H (February 2009). "Diverse Genome-wide Association Studies Associate the IL12/IL23 Pathway with Crohn Disease". Am. J. Hum. Genet. 84 (3): 399–405. doi:10.1016/j.ajhg.2009.01.026. PMC 2668006. PMID 19249008. 
  4. ^ Rubie C (Feb 2014). "Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells.". J Transl Med. 12. doi:10.1186/1479-5876-12-48. PMID 24559209. 

External links[edit]

  • "Chemokine Receptors: CCR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.