IL13RA2

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Interleukin 13 receptor, alpha 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IL13RA2 ; CD213A2; CT19; IL-13R; IL13BP
External IDs OMIM300130 MGI1277954 HomoloGene534 GeneCards: IL13RA2 Gene
RNA expression pattern
PBB GE IL13RA2 206172 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3598 16165
Ensembl ENSG00000123496 ENSMUSG00000031289
UniProt Q14627 O88786
RefSeq (mRNA) NM_000640 NM_008356
RefSeq (protein) NP_000631 NP_032382
Location (UCSC) Chr HG1462_PATCH:
114.24 – 114.26 Mb
Chr X:
147.38 – 147.43 Mb
PubMed search [1] [2]

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.[1]

Function[edit]

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.[1]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.