Mitochondrial ribosomal protein L18

MRPL18
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y
Identifiers
Aliases	MRPL18, L18mt, MRP-L18, HSPC071, mitochondrial ribosomal protein L18
External IDs	OMIM: 611831; MGI: 1914931; HomoloGene: 8566; GeneCards: MRPL18; OMA:MRPL18 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q25.3 Start 159,789,812 bp End 159,798,436 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A1 Start 13,130,236 bp End 13,135,232 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte olfactory bulb palpebral conjunctiva muscle of thigh anterior cingulate cortex mucosa of transverse colon smooth muscle tissue prefrontal cortex C1 segment Top expressed in blastocyst primary oocyte secondary oocyte embryo heart proximal tubule quadriceps femoris muscle epiblast embryo morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome 5S rRNA binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome intracellular anatomical structure extracellular space mitochondrial large ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination rRNA import into mitochondrion protein biosynthesis transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29074 67681 Ensembl ENSG00000112110 ENSMUSG00000057388 UniProt Q9H0U6 Q9CQL5 RefSeq (mRNA) NM_014161 NM_001318817 NM_026310 RefSeq (protein) NP_001305746 NP_054880 NP_080586 Location (UCSC) Chr 6: 159.79 – 159.8 Mb Chr 17: 13.13 – 13.14 Mb PubMed search
Wikidata
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39S ribosomal protein L18, mitochondrial is a protein that in humans is encoded by the MRPL18 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L18P ribosomal protein family. Three polymorphic sites exist in this gene, one of which is three nt in length which causes an extra aa near the N-terminus.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.