CUMYL-PICA

CUMYL-PICA
Legal status
Legal status	CA: Schedule II;
Identifiers
	IUPAC name 1-pentyl-N-(2-phenylpropan-2-yl)-1H-indole-3-carboxamide;
CAS Number	1400742-32-6;
PubChem CID	86273678;
ChemSpider	34450887;
CompTox Dashboard (EPA)	DTXSID601017202 ;
Chemical and physical data
Formula	C23H28N2O
Molar mass	348.49 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(NC(C)(C)C1=CC=CC=C1)C2=CN(CCCCC)C3=C2C=CC=C3;
	InChI InChI=1S/C23H28N2O/c1-4-5-11-16-25-17-20(19-14-9-10-15-21(19)25)22(26)24-23(2,3)18-12-7-6-8-13-18/h6-10,12-15,17H,4-5,11,16H2,1-3H3,(H,24,26); Key:RCXFMWJQOYCIQU-UHFFFAOYSA-N;

CUMYL-PICA (SGT-56) is an indole-3-carboxamide based synthetic cannabinoid. It is the α,α-dimethylbenzyl analogue of SDB-006.^[1] It was briefly sold in New Zealand during 2013 as an ingredient of at the time legal synthetic cannabis products, but the product containing CUMYL-BICA and CUMYL-PICA was denied an interim licensing approval under the Psychoactive Substances regulatory scheme, due to reports of adverse events in consumers.^[2] CUMYL-PICA acts as a potent agonist for the cannabinoid receptors, with approximately 20x selectivity for CB₁, having an EC₅₀ of 0.66nM for human CB₁ receptors and 13nM for human CB₂ receptors.^[3]

References

^ "CUMYL-PICA". Cayman Chemical. Retrieved 8 July 2015.
^ The Risk Assessment Score Table. New Zealand Ministry of Health, 27 September 2013
^ Bowden; et al. (11 April 2013). "Patent WO 2014167530 - Cannabinoid compounds". New Zealand Patent application 623626. Retrieved 11 July 2015.

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[1] "CUMYL-PICA". Cayman Chemical. Retrieved 8 July 2015.

[2] The Risk Assessment Score Table. New Zealand Ministry of Health, 27 September 2013

[3] Bowden; et al. (11 April 2013). "Patent WO 2014167530 - Cannabinoid compounds". New Zealand Patent application 623626. Retrieved 11 July 2015.

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See also

References