MRPL11

From Wikipedia, the free encyclopedia
Jump to: navigation, search
MRPL11
PBB Protein MRPL11 image.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPL11, L11MT, MRP-L11, CGI-113, mitochondrial ribosomal protein L11
External IDs MGI: 2137215 HomoloGene: 6768 GeneCards: MRPL11
RNA expression pattern
PBB GE MRPL11 219162 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016050
NM_170738
NM_170739

NM_025553

RefSeq (protein)

NP_057134
NP_733934
NP_733935

NP_079829.1
NP_079829

Location (UCSC) Chr 11: 66.44 – 66.47 Mb Chr 19: 4.96 – 4.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L11, mitochondrial is a protein that in humans is encoded by the MRPL11 gene.[3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode different isoforms. Pseudogenes corresponding to this gene are found on chromosomes 5q and 12q.[3]

References[edit]

Further reading[edit]