60S ribosomal protein L13

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RPL13
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesRPL13, BBC1, D16S444E, D16S44E, L13, ribosomal protein L13
External IDsMGI: 3642685 HomoloGene: 5568 GeneCards: RPL13
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for RPL13
Genomic location for RPL13
Band16q24.3|17p11.2Start89,560,657 bp[1]
End89,566,828 bp[1]
RNA expression pattern
PBB GE RPL13 212734 x at fs.png

PBB GE RPL13 208929 x at fs.png

PBB GE RPL13 212191 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033251
NM_000977
NM_001243130
NM_001243131

n/a

RefSeq (protein)

NP_000968
NP_001230059
NP_001230060
NP_150254

n/a

Location (UCSC)Chr 16: 89.56 – 89.57 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal protein L13 is a protein that in humans is encoded by the RPL13 gene.[4][5]

Function[edit]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Transcript variants derived from alternative splicing and/or alternative polyadenylation exist; these variants encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[5]

Interactions[edit]

RPL13 has been shown to interact with CDC5L.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167526 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ "Mouse PubMed Reference:".
  4. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (August 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  5. ^ a b "Entrez Gene: RPL13 ribosomal protein L13".
  6. ^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further reading[edit]