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Ribosomal protein L6
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RPL6 ; L6; SHUJUN-2; TAXREB107; TXREB1
External IDs OMIM603703 HomoloGene31001 GeneCards: RPL6 Gene
Species Human Mouse
Entrez 6128 19988
Ensembl ENSG00000089009 ENSMUSG00000029614
UniProt Q02878 P47911
RefSeq (mRNA) NM_000970 NM_011290
RefSeq (protein) NP_000961 NP_035420
Location (UCSC) Chr 12:
112.41 – 112.42 Mb
Chr 5:
121.2 – 121.21 Mb
PubMed search [1] [2]

60S ribosomal protein L6 is a protein that in humans is encoded by the RPL6 gene.[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[3]


RPL6 has been shown to interact with Basic fibroblast growth factor.[4]


  1. ^ Zaman GJ (May 1993). "Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6". Nucleic Acids Res 21 (7): 1673. doi:10.1093/nar/21.7.1673. PMC 309386. PMID 8479925. 
  2. ^ Morita T, Sato T, Nyunoya H, Tsujimoto A, Takahara J, Irino S, Shimotohno K (Apr 1993). "Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I". AIDS Res Hum Retroviruses 9 (2): 115–21. doi:10.1089/aid.1993.9.115. PMID 8457378. 
  3. ^ a b "Entrez Gene: RPL6 ribosomal protein L6". 
  4. ^ Shen, B; Arese M; Gualandris A; Rifkin D B (Nov 1998). "Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107". Biochem. Biophys. Res. Commun. (UNITED STATES) 252 (2): 524–8. doi:10.1006/bbrc.1998.9677. ISSN 0006-291X. PMID 9826564. 

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