RU-28306

RU-28306
Identifiers
CAS Number	73625-11-3;
PubChem CID	194528;
ChemSpider	168785;
CompTox Dashboard (EPA)	DTXSID90994429 ;
Chemical and physical data
Formula	C13H16N2
Molar mass	200.279 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c13c(C2)cccc1ncc3CC2N(C)C;
	InChI InChI=1S/C13H16N2/c1-15(2)11-6-9-4-3-5-12-13(9)10(7-11)8-14-12/h3-5,8,11,14H,6-7H2,1-2H3; Key:BQOANWOQEHVATQ-UHFFFAOYSA-N;

RU-28306 is a tricyclic tryptamine derivative which acts as a serotonin receptor agonist, with selectivity for 5-HT₁ and 5-HT₂ subtypes. It can be regarded either as a conformationally constrained derivative of DMT, or a structurally simplified analogue of LSD, but the binding affinity of racemic RU-28306 is closer to that of DMT, though with relatively higher affinity for 5-HT₂ subtypes and lower for 5-HT₁.^[1]

References

^ Taylor EW, Nikam S, Weck B, Martin A, Nelson D. Relative selectivity of some conformationally constrained tryptamine analogs at 5-HT1, 5-HT1A and 5-HT2 recognition sites. Life Sciences. 1987 Oct 19;41(16):1961-9. PMID 3657392

[1] Taylor EW, Nikam S, Weck B, Martin A, Nelson D. Relative selectivity of some conformationally constrained tryptamine analogs at 5-HT1, 5-HT1A and 5-HT2 recognition sites. Life Sciences. 1987 Oct 19;41(16):1961-9. PMID 3657392

[1]

See also

References