Androgen replacement therapy

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Androgen replacement therapy

Androgen replacement therapy (ART), often referred to as testosterone replacement therapy (TRT), is a form of hormone therapy in which androgens, often testosterone, are replaced. ART is often prescribed to counter the effects of male hypogonadism. It typically involves the administration of testosterone through injections, skin creams, patches, gels, or subcutaneous pellets.

ART is also prescribed to lessen the effects or delay the onset of normal male aging. However, this is controversial and is the subject of ongoing clinical trials.[1] As men enter middle age they may notice changes caused by a relative decline in testosterone: fewer erections, fatigue, thinning skin, declining muscle mass and strength, more body fat. Dissatisfaction with these changes causes some middle age men to seek ART.

Medical uses[edit]


Androgen replacement is the classic treatment of hypogonadism.[2] It is also used in men who have lost the ability to produce androgens due to disease or its treatment.[3]


The risks of diabetes and of testosterone deficiency in men over 45 (i.e., hypogonadism, specifically hypoandrogenism) are strongly correlated. Testosterone replacement therapies have been shown to improve blood glucose management.[4][5] Still, "it is prudent not to start testosterone therapy in men with diabetes solely for the purpose of improving metabolic control if they show no signs and symptoms of hypogonadism."[6]


Androgen replacement is also used in postmenopausal women, for instance to increase sexual desire and to prevent or treat osteoporosis.[7] The androgens used for androgen replacement in women include testosterone (and esters), prasterone (dehydroepiandrosterone; DHEA) (and the ester prasterone enanthate), methyltestosterone, nandrolone decanoate, and tibolone, among others.[7]

Androgen replacement therapy formulations and dosages used in women
Route Medication Form(s) Major brand name(s) Dose range Frequency
Oral Testosterone undecanoatea Capsule Andriol 40–80 mg Every 1–2 days
Oral Methyltestosteroneb Tablet Metandren; Estratest 0.5–10 mg Daily
Oral Normethandronea,b Tablet Ginecoside 5 mg Daily
Oral Tibolonea Tablet Livial 1.25–2.5 mg Daily
Oral Prasterone (dehydroepiandrosterone)c Tablet N/A 25–100 mg Daily
Sublingual Testosteroned Tablet N/A 0.25–0.5 mg Daily
Sublingual Methyltestosterone Tablet Metandren 0.25 mg Daily
Transdermal Testosteronea Patch Intrinsa 150–300 μg/day Every 3–4 days
Transdermal Testosterone Cream; Gel AndroGel 5–10 mg Daily
Vaginal Testosteroned Cream; Gel N/A Unspecified Every 1–3 days
Vaginal Prasterone (dehydroepiandrosterone) Insert Intrarosa 6.5 mg Daily
Intramuscular Testosterone enanthateb Oil Delatestryl; Ditate-DS 25–100 mg Every 4–6 weeks
Intramuscular Testosterone cypionateb Oil Depo-Testosterone; Depo-Testadiol 25–100 mg Every 4–6 weeks
Intramuscular Testosterone enanthate benzilic acid hydrazoneb,e Oil Climacteron 150 mg Every 4–8 weeks
Intramuscular Nandrolone decanoate Oil Deca-Durabolin 25–50 mg Every 6–12 weeks
Intramuscular Prasterone enanthatea,b Oil Gynodian Depot 200 mg Every 4–6 weeks
Subcutaneous Testosterone Implant Testopel 50–100 mg Every 3–6 months
Footnotes: a = Not available or no longer available in the United States. b = Alone and/or in combination with an estrogen. c = Over-the-counter. d = Compounded only. e = Discontinued. Miscellaneous: Direct link to table. Sources: General: [8][9][10][11][12][13][14][15][16][7] Specific: [17][18][19][20][21]

Adverse effects[edit]

The Food and Drug Administration (FDA) stated in 2015 that neither the benefits nor the safety of testosterone have been established for low testosterone levels due to aging.[22] The FDA has required that testosterone labels include warning information about the possibility of an increased risk of heart attacks and stroke.[22]

Heart disease[edit]

On January 31, 2014, reports of strokes, heart attacks, and deaths in men taking testosterone-replacement led the FDA to announce that it would be investigating this issue.[23] The FDA's action followed three peer-reviewed studies of increased cardiovascular events and deaths.[24] Due to an increased rate of adverse cardiovascular events compared to a placebo group, a randomized trial stopped early.[25] Also, in November 2013, a study reported an increase in deaths and heart attacks in older men.[26] Even after a correction was published, the "Androgen Study Group", a group with many members who have relationships with drug companies in the testosterone market,[27][28] requested JAMA to retract the article as misleading due to substantial residual errors.[29] Concerns have been raised that testosterone was being widely marketed ahead of large randomized controlled trials.[30] As a result of the "potential for adverse cardiovascular outcomes", the FDA announced, in September 2014, a review of the appropriateness and safety of testosterone replacement therapy.[31][32][33]


Other significant adverse effects of testosterone supplementation include acceleration of pre-existing prostate cancer growth in individuals who have undergone androgen deprivation; increased hematocrit, which can require venipuncture in order to treat; and, exacerbation of sleep apnea.[34] Adverse effects may also include minor side-effects such as acne and oily skin, as well as, significant hair loss and/or thinning of the hair, which may be prevented with 5-alpha reductase inhibitors ordinarily used for the treatment of benign prostatic hyperplasia, such as finasteride.[35] Exogenous testosterone may also cause suppression of spermatogenesis, leading to, in some cases, infertility.[36] It is recommended that physicians screen for prostate cancer with a digital rectal exam and prostate-specific antigen (PSA) level before starting therapy, and monitor PSA and hematocrit levels closely during therapy.[37]

Some studies argue that ART increases the risk of prostate cancer, although the results are not conclusive.[38]

Society and culture[edit]


As of September 2014, testosterone replacement therapy has been under review for appropriateness and safety by the Food and Drug Administration due to the "potential for adverse cardiovascular outcomes".[31][32][33]

Frequency of use[edit]

In the United States usage increased from 0.5% in 2002 to 3.2% in 2013 and have since decreased to 1.7% in 2016.[39]

A UK study in 2013 showed that prescriptions for testosterone replacement, particularly transdermal products, almost doubled between 2000 and 2010.[40]


There are several artificial androgens, many of which are manipulations of the testosterone molecule referred to as anabolic-androgenic steroids. Androgen replacement is administered by patch, tablet, pill, cream or gel; or depot injections given into fat or muscle.[23]


In addition, a number of other effects of testosterone have led to research into possible therapeutic roles in:

See also[edit]


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  3. ^ Giwercman, A; Lundberg Giwercman, Y (2015). "Hypogonadism in young men treated for cancer". Hormones (Athens, Greece). 14 (4): 590–7. doi:10.14310/horm.2002.1650. PMID 26859600. open access publication – free to read
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