Calcium-binding protein
Calcium-binding proteins are proteins that participate in calcium cell signalling pathways by binding to Ca2+.
The most ubiquitous Ca2+-sensing protein, found in all eukaryotic organisms including yeasts, is calmodulin.
Intracellular storage and release of Ca2+ from the sarcoplasmic reticulum is associated with the high-capacity, low-affinity calcium-binding protein calsequestrin.[1]
With their role in signal transduction, calcium-binding proteins contribute to all aspects of the cell's functioning, from homeostasis to learning and memory.[2]
For example, the neuron-specific calexcitin has been found to have an excitatory effect on neurons, and interacts with proteins that control the firing state of neurons, such as the voltage-dependent potassium channel.[3]
See also
- Vitamin D-dependent calcium-binding protein
- www.quincybioscience.com
- Wikipedia:MeSH_D12.776#MeSH_D12.776.157.125_---_calcium-binding_proteins
References
- ^ Siegel, George (Ed.). Basic neurochemistry : molecular, cellular and medical aspects. Lippincott Williams and Wilkins / 1999 ISBN 0-397-51820-X
- ^ Prevagen Improves Memory. PREVAGEN®. Retrieved 2013-12-29.
- ^ Nelson T, Cavallaro S, Yi C, McPhie D, Schreurs B, Gusev P, Favit A, Zohar O, Kim J, Beushausen S, Ascoli G, Olds J, Neve R, Alkon D (1996). "Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability". PNAS. 93 (24): 13808–13. doi:10.1073/pnas.93.24.13808. PMC 19433. PMID 8943017.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
3. Yáñez M, Gil-Longo J, Campos-Toimil M. Calcium binding proteins. Adv Exp Med Biol. 2012;740:461-82. doi: 10.1007/978-94-007-2888-2_19.
External links
- Calcium-Binding+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)