Imgatuzumab
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Monoclonal antibody | |
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Type | Whole antibody |
Source | Humanized (from rat) |
Target | EGFR |
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ChemSpider |
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Chemical and physical data | |
Formula | C6434H9942N1718O2016S44 |
Molar mass | 145028.96 g·mol−1 |
Imgatuzumab (INN) is a humanized monoclonal antibody designed for the treatment of cancer. It is an anti-EGFR antibody[1] that acts as an immunomodulator.[2][3]
The drug was developed by Genentech/Roche.
References
- ^ Kol A, Terwisscha van Scheltinga A, Pool M, Gerdes C, de Vries E, de Jong S (July 2017). "ADCC responses and blocking of EGFR-mediated signaling and cell growth by combining the anti-EGFR antibodies imgatuzumab and cetuximab in NSCLC cells". Oncotarget. 8 (28): 45432–45446. doi:10.18632/oncotarget.17139. PMC 5542198. PMID 28467975.
- ^ World Health Organization (2012). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 107" (PDF). WHO Drug Information. 26 (2).
- ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Imgatuzumab, American Medical Association.
Angiopoietin |
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CNTF |
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EGF (ErbB) |
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FGF |
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HGF (c-Met) |
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IGF |
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LNGF (p75NTR) |
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PDGF |
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RET (GFL) |
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SCF (c-Kit) |
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TGFβ |
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Trk |
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VEGF |
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Others |
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