CCL1
Appearance
chemokine (C-C motif) ligand 1 | |||||||
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Identifiers | |||||||
Symbol | CCL1 | ||||||
Alt. symbols | SCYA1, I-309, TCA3, P500, SISe | ||||||
NCBI gene | 6346 | ||||||
HGNC | 10609 | ||||||
OMIM | 182281 | ||||||
PDB | 1EL0 | ||||||
RefSeq | NM_002981 | ||||||
UniProt | P22362 | ||||||
Other data | |||||||
Locus | Chr. 17 q11.2 | ||||||
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Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family of inflammatory cytokines known as chemokines.[1] CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8.[2] This chemokine resides in a large cluster of CC chemokines on human chromosome 17.
References
- ^ Miller MD, Krangel MS (April 1992). "The human cytokine I-309 is a monocyte chemoattractant". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2950–4. doi:10.1073/pnas.89.7.2950. PMC 48781. PMID 1557400.
- ^ Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B (July 1997). "Identification of CCR8, the receptor for the human CC chemokine I-309". J. Biol. Chem. 272 (28): 17251–4. doi:10.1074/jbc.272.28.17251. PMID 9211859.