|Source||Humanized (from mouse)|
|Chemical and physical data|
|Molar mass||146.44 kg/mol|
|(what is this?)|
Mogamulizumab (trade name Poteligeo) is a humanized, afucosylated monoclonal antibody targeting CC chemokine receptor 4 (CCR4). The US FDA approved it in August 2018 for treatment of relapsed or refractory mycosis fungoides and Sézary disease. It was approved in Japan in 2012 for the treatment of relapsed or refractory CCR4+ adult T-cell leukemia/lymphoma (ATCLL) and in 2014 for relapsed or refractory CCR4+ cutaneous T cell lymphoma (CTCL). The latter approval was based on study with 28 subjects.
The precursor to mogamulizumab was a mouse anti-human CCR4 IgG1 mAb (KM2160), that was made in 1996 in a collaboration between Kouji Matsushima of University of Tokyo and Kyowa Hakko Kirin. Kyowa humanized it, and expressed the humanized gene in a CHO cell line in which FUT8 had been knocked out, which produced antibodies with no fucose in the Fc region. This is thought to enhance its antibody-dependent cell-mediated cytotoxicity. It was first tested in humans in 2007.
Kyowa licensed rights for use outside of cancer to Amgen in 2008 for $100 million up front and $420 million in biodollars. Amgen ran a Phase I study to explore its use in asthma. Amgen terminated the agreement in 2014.
- "Mogamulizumab - Kyowa Hakko Kirin". AdisInsight. Retrieved 11 May 2018.
- Yu, X; Marshall, MJE; Cragg, MS; Crispin, M (June 2017). "Improving Antibody-Based Cancer Therapeutics Through Glycan Engineering". BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 31 (3): 151–166. doi:10.1007/s40259-017-0223-8. PMID 28466278.
- Broccoli, A; Argnani, L; Zinzani, PL (November 2017). "Peripheral T-cell lymphomas: Focusing on novel agents in relapsed and refractory disease". Cancer treatment reviews. 60: 120–129. doi:10.1016/j.ctrv.2017.09.002. PMID 28946015.
- Ueda, R (2015). "Clinical Application of Anti-CCR4 Monoclonal Antibody". Oncology. 89 Suppl 1: 16–21. doi:10.1159/000431059. PMID 26550987.
- "Available Agents: Mogamulizumab". NCI Formulary. Retrieved 11 May 2018.
- Carroll, John (August 25, 2017). "After a long clinical odyssey, the FDA tapped this PhIII anti-CCR4 as a 'breakthrough' lymphoma drug". Endpoints.
- Pease, JE; Horuk, R (May 2014). "Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4". Expert opinion on drug discovery. 9 (5): 467–83. doi:10.1517/17460441.2014.897324. PMID 24641500.
- Adamson, Laurie (22 January 2018). "Mogamulizumab Receives Priority Review for CTCL - ASH Clinical News". ASH Clinical News.
|This monoclonal antibody-related article is a stub. You can help Wikipedia by expanding it.|
|This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.|