C-C chemokine receptor type 7

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Chemokine (C-C motif) receptor 7
Symbols CCR7 ; BLR2; CC-CKR-7; CCR-7; CD197; CDw197; CMKBR7; EBI1
External IDs OMIM600242 MGI103011 HomoloGene1387 IUPHAR: 64 ChEMBL: 4594 GeneCards: CCR7 Gene
RNA expression pattern
PBB GE CCR7 206337 at tn.png
More reference expression data
Species Human Mouse
Entrez 1236 12775
Ensembl ENSG00000126353 ENSMUSG00000037944
UniProt P32248 P47774
RefSeq (mRNA) NM_001301714 NM_001301713
RefSeq (protein) NP_001288643 NP_001288642
Location (UCSC) Chr 17:
40.55 – 40.57 Mb
Chr 11:
99.14 – 99.16 Mb
PubMed search [1] [2]

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene.[1] Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (CCL19/ELC) and (C-C motif) ligand 21 (CCL21).[2]

CCR7 has also recently been designated CD197 (cluster of differentiation 197).


The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells home to secondary lymphoid organs, such as lymph nodes, as well as stimulate dendritic cell maturation.

Clinical significance[edit]

CCR7 is expressed by various cancer cells, such as nonsmall lung cancer, gastric cancer and oesophageal cancer.[3][4][5] Expression of CCR7 by cancer cells is linked with metastasis to lymph nodes.[6]


  1. ^ Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (Apr 1993). "Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors". J Virol 67 (4): 2209–20. PMC 240341. PMID 8383238. 
  2. ^ F. Balkwill, Cancer and the Chemokine Network, Nature reviews, 2004
  3. ^ Mashino, K. et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res. 62, 2937–2941 (2002)
  4. ^ Takanami, I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. Int. J. Cancer 105, 186–189 (2003)
  5. ^ Ding, Y. et al. Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin. Cancer Res. 9, 3406–3412 (2003)
  6. ^ Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz MA (June 2007). "Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling". Cancer Cell 11 (6): 526–38. doi:10.1016/j.ccr.2007.04.020. PMID 17560334. 

External links[edit]

  • "Chemokine Receptors: CCR7". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.