In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly because a deficiency of cytokine receptors has now been directly linked to certain debilitating immunodeficiency states. In this regard, and also because the redundancy and pleiotropy of cytokines are a consequence of their homologous receptors, many authorities are now of the opinion that a classification of cytokine receptors would be more clinically and experimentally useful.
A classification of cytokine receptors based on their three-dimensional structure has been attempted. (Such a classification, though seemingly cumbersome, provides several unique perspectives for attractive pharmacotherapeutic targets.)
- Type I cytokine receptors, whose members have certain conserved motifs in their extracellular amino-acid domain. The IL-2 receptor belongs to this chain, whose γ-chain (common to several other cytokines) deficiency is directly responsible for the x-linked form of Severe Combined Immunodeficiency (X-SCID).
- Type II cytokine receptors, whose members are receptors mainly for interferons.
- Immunoglobulin (Ig) superfamily, which are ubiquitously present throughout several cells and tissues of the vertebrate body
- Tumor necrosis factor receptor family, whose members share a cysteine-rich common extracellular binding domain, and includes several other non-cytokine ligands like receptors, CD40, CD27 and CD30, besides the ligands on which the family is named (TNF).
- Chemokine receptors, two of which acting as binding proteins for HIV (CXCR4 and CCR5). They are G protein coupled receptors.
- TGF beta receptors
|type I cytokine receptor||Certain conserved motifs in their extracellular amino-acid domain. Connected to Janus kinase (JAK) family of tyrosine kinases||JAK phosphorylate and activate downstream proteins involved in their signal transduction pathways|
|type II cytokine receptor|
|Many members of the immunoglobulin superfamily||Share structural homology with immunoglobulins (antibodies), cell adhesion molecules, and even some cytokines.|
|Tumor necrosis factor receptor family||cysteine-rich common extracellular binding domain|
|chemokine receptors||Seven transmembrane helix||G protein-coupled|
|TGF beta receptors|
Cytokine receptors may be both membrane-bound and soluble. Soluble cytokine receptors are extremely common regulators of cytokine function. Soluble cytokine receptors typically consist of the extracellular portions of membrane-bound receptors. .
- Arimont A, Sun S, Smit MJ, Leurs R, de Esch IJ, de Graaf C (2017). "Structural Analysis of Chemokine Receptor-Ligand Interactions". J Med Chem. doi:10.1021/acs.jmedchem.6b01309. PMID 28165741.
- Heaney ML1, Golde DW (1998). "Soluble receptors in human disease". Journal of Leukocyte Biology. 64 (2): 135–146. PMID 9715251.
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