EPH receptor A1

EPHA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K1K, 2K1L, 3HIL, 3KKA
Identifiers
Aliases	EPHA1, Epha1, 5730453L17Rik, AL033318, Eph, Esk, EPHT, EPHT1, EPH receptor A1, EPH
External IDs	OMIM: 179610; MGI: 107381; HomoloGene: 3835; GeneCards: EPHA1; OMA:EPHA1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	143,408,856 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	42,350,202 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; right uterine tube; ; right lobe of liver; ; minor salivary glands; ; vagina; ; left lobe of thyroid gland; ; ectocervix; ; mucosa of transverse colon; ; right lung;
	Top expressed in
	lip; ; tail of embryo; ; esophagus; ; embryo; ; epiblast; ; female urethra; ; right kidney; ; ascending aorta; ; male urethra; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; transmembrane-ephrin receptor activity; kinase activity; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; protein kinase binding; ephrin receptor activity; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; cytoplasm; neuron projection; receptor complex;
Biological process	somatic stem cell population maintenance; negative regulation of protein kinase activity; activation of GTPase activity; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell-matrix adhesion; positive regulation of cell migration; regulation of GTPase activity; positive regulation of angiogenesis; protein phosphorylation; cell surface receptor signaling pathway; negative regulation of cell migration; cell adhesion; angiogenesis; positive regulation of cell population proliferation; protein autophosphorylation; peptidyl-tyrosine phosphorylation; substrate adhesion-dependent cell spreading; positive regulation of stress fiber assembly; ephrin receptor signaling pathway; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	2041
	13835
	ENSG00000146904; ENSG00000284816
	ENSMUSG00000029859
	P21709
	Q60750
	NM_005232
	NM_023580
	NP_005223
	NP_076069
	Wikidata
View/Edit Human	View/Edit Mouse

EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c ENSG00000284816 GRCh38: Ensembl release 89: ENSG00000146904, ENSG00000284816 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029859 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
^ "Entrez Gene: EPHA1 EPH receptor A1".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading