EPH receptor B4

EPHB4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BBA, 2E7H, 2QKQ, 2VWU, 2VWV, 2VWW, 2VWX, 2VWY, 2VWZ, 2VX0, 2VX1, 2X9F, 2XVD, 2YN8, 3ZEW, 4AW5, 4BB4, 2HLE
Identifiers
Aliases	EPHB4, Ephb4, AI042935, Htk, MDK2, Myk1, Tyro11, EPH receptor B4, HTK, MYK1, TYRO11, HFASD, CMAVM2, LMPHM7
External IDs	OMIM: 600011 MGI: 104757 HomoloGene: 20939 GeneCards: EPHB4
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,827,523 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,376,931 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; right adrenal gland; ; left adrenal gland; ; right lung; ; canal of the cervix; ; pancreatic ductal cell; ; myometrium; ; stromal cell of endometrium; ; spleen; ; gallbladder;
	Top expressed in
	saccule; ; atrium; ; yolk sac; ; left ventricle; ; aortic valve; ; lip; ; maxillary prominence; ; otic placode; ; internal carotid artery; ; lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; ephrin receptor activity; transmembrane-ephrin receptor activity;
Cellular component	integral component of membrane; cytosol; membrane; plasma membrane; integral component of plasma membrane; extracellular region; extracellular exosome; neuron projection; receptor complex;
Biological process	phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; heart morphogenesis; cell migration involved in sprouting angiogenesis; multicellular organism development; protein phosphorylation; cell adhesion; angiogenesis; protein autophosphorylation; peptidyl-tyrosine phosphorylation; ephrin receptor signaling pathway; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	2050
	13846
	ENSG00000196411
	ENSMUSG00000029710
	P54760
	P54761
	NM_004444
	NM_001159571; NM_010144
	NP_004435
	NP_001153043; NP_034274
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196411 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029710 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT (Jun 1994). "Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily". J Biol Chem. 269 (19): 14211–8. PMID 8188704.
^ "Entrez Gene: EPHB4 EPH receptor B4".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading