Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78gene.
This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified.
Rogers MA, Winter H, Langbein L, et al. (2000). "Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain". J. Invest. Dermatol.114 (3): 464–72. doi:10.1046/j.1523-1747.2000.00910.x. PMID10692104.
Hesse M, Magin TM, Weber K (2002). "Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18". J. Cell. Sci.114 (Pt 14): 2569–75. PMID11683385.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Hesse M, Zimek A, Weber K, Magin TM (2004). "Comprehensive analysis of keratin gene clusters in humans and rodents". Eur. J. Cell Biol.83 (1): 19–26. doi:10.1078/0171-9335-00354. PMID15085952.
Rogers MA, Edler L, Winter H, et al. (2005). "Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13". J. Invest. Dermatol.124 (3): 536–44. doi:10.1111/j.0022-202X.2004.23530.x. PMID15737194.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res.16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID16344560.