From Wikipedia, the free encyclopedia
Jump to: navigation, search
Tropomyosin 1 (alpha)
Protein TPM1 PDB 1c1g.png
PDB rendering based on 1c1g.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TPM1 ; C15orf13; CMD1Y; CMH3; HTM-alpha; LVNC9; TMSA
External IDs OMIM191010 MGI98809 HomoloGene121635 GeneCards: TPM1 Gene
RNA expression pattern
PBB GE TPM1 210986 s at tn.png
PBB GE TPM1 206116 s at tn.png
PBB GE TPM1 210987 x at tn.png
More reference expression data
Species Human Mouse
Entrez 7168 22003
Ensembl ENSG00000140416 ENSMUSG00000032366
UniProt P09493 Q545Y3
RefSeq (mRNA) NM_000366 NM_024427
RefSeq (protein) NP_000357 NP_077745
Location (UCSC) Chr 15:
63.33 – 63.36 Mb
Chr 9:
66.82 – 66.85 Mb
PubMed search [1] [2]

Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene.[1]

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.[2]


TPM1 has been shown to interact with TPM2.[3]


  1. ^ Mogensen J, Kruse TA, Borglum AD (Jun 1999). "Refined localization of the human alpha-tropomyosin gene (TPM1) by genetic mapping". Cytogenet Cell Genet 84 (1-2): 35–6. doi:10.1159/000015207. PMID 10343096. 
  2. ^ "Entrez Gene: TPM1 tropomyosin 1 (alpha)". 
  3. ^ Brown, H R; Schachat F H (Apr 1985). "Renaturation of skeletal muscle tropomyosin: implications for in vivo assembly". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 82 (8): 2359–63. doi:10.1073/pnas.82.8.2359. ISSN 0027-8424. PMC 397557. PMID 3857586. 

Further reading[edit]

External links[edit]