MYL3

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Myosin, light chain 3, alkali; ventricular, skeletal, slow
Identifiers
Symbols MYL3 ; CMH8; MLC1SB; MLC1V; VLC1
External IDs OMIM160790 MGI97268 HomoloGene20099 GeneCards: MYL3 Gene
RNA expression pattern
PBB GE MYL3 205589 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4634 17897
Ensembl ENSG00000160808 ENSMUSG00000059741
UniProt P08590 P09542
RefSeq (mRNA) NM_000258 NM_010859
RefSeq (protein) NP_000249 NP_034989
Location (UCSC) Chr 3:
46.9 – 46.92 Mb
Chr 9:
110.76 – 110.77 Mb
PubMed search [1] [2]

Myosin light chain 3 is a protein that in humans is encoded by the MYL3 gene.[1][2][3]

MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.[3]

References[edit]

  1. ^ Shi Q, Li RK, Mickle DA, Jackowski G (Feb 1993). "Analysis of the upstream regulatory region of human ventricular myosin light chain 1 gene". J Mol Cell Cardiol 24 (11): 1221–9. doi:10.1016/0022-2828(92)93089-3. PMID 1479618. 
  2. ^ Cohen-Haguenauer O, Barton PJ, Van Cong N, Cohen A, Masset M, Buckingham M, Frezal J (Apr 1989). "Chromosomal assignment of two myosin alkali light-chain genes encoding the ventricular/slow skeletal muscle isoform and the atrial/fetal muscle isoform (MYL3, MYL4)". Hum Genet 81 (3): 278–82. doi:10.1007/bf00279004. PMID 2784124. 
  3. ^ a b "Entrez Gene: MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow". 

Further reading[edit]

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