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Myosin XVA
Symbols MYO15A ; DFNB3; MYO15
External IDs OMIM602666 MGI1261811 HomoloGene56504 GeneCards: MYO15A Gene
RNA expression pattern
PBB GE MYO15A 220288 at tn.png
More reference expression data
Species Human Mouse
Entrez 51168 17910
Ensembl ENSG00000091536 ENSMUSG00000042678
UniProt Q9UKN7 Q9QZZ4
RefSeq (mRNA) NM_016239 NM_001103171
RefSeq (protein) NP_057323 NP_001096641
Location (UCSC) Chr 17:
18.01 – 18.08 Mb
Chr 11:
60.47 – 60.53 Mb
PubMed search [1] [2]

Myosin-XV is a protein that in humans is encoded by the MYO15A gene.[1][2]


Read-through transcript containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined.[2]


This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea.[2]

Clinical significance[edit]

Mutations in this gene have been associated with profound, congenital, neurosensory, non syndromic deafness .[3] This gene is located within the Smith-Magenis syndrome region on chromosome 17.[2]


  1. ^ Wang A, Liang Y, Fridell RA, Probst FJ, Wilcox ER, Touchman JW, Morton CC, Morell RJ, Noben-Trauth K, Camper SA, Friedman TB (Jun 1998). "Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3". Science 280 (5368): 1447–51. doi:10.1126/science.280.5368.1447. PMID 9603736. 
  2. ^ a b c d "Entrez Gene: MYO15A myosin XVA". 
  3. ^ Riahi, Z; Bonnet, C; Zainine, R; Louha, M; Bouyacoub, Y; Laroussi, N; Chargui, M; Kefi, R; Jonard, L; Dorboz, I; Hardelin, J. P.; Salah, S. B.; Levilliers, J; Weil, D; McElreavey, K; Boespflug, O. T.; Besbes, G; Abdelhak, S; Petit, C (2014). "Whole Exome Sequencing Identifies New Causative Mutations in Tunisian Families with Non-Syndromic Deafness". PLoS ONE 9 (6): e99797. doi:10.1371/journal.pone.0099797. PMID 24926664.  edit

Further reading[edit]