KRT81

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Keratin 81
Identifiers
Symbols KRT81 ; HB1; Hb-1; KRTHB1; MLN137; ghHkb1; hHAKB2-1
External IDs OMIM602153 HomoloGene55645 GeneCards: KRT81 Gene
RNA expression pattern
PBB GE KRT81 213711 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3887 64818
Ensembl ENSG00000205426 ENSMUSG00000067615
UniProt Q14533 Q9ERE2
RefSeq (mRNA) NM_002281 NM_001166157
RefSeq (protein) NP_002272 NP_001159629
Location (UCSC) Chr 12:
52.68 – 52.69 Mb
Chr 15:
101.46 – 101.46 Mb
PubMed search [1] [2]

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.[1][2][3]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.[3]

References[edit]

  1. ^ Rogers MA, Nischt R, Korge B, Krieg T, Fink TM, Lichter P, Winter H, Schweizer J (Nov 1995). "Sequence data and chromosomal localization of human type I and type II hair keratin genes". Exp Cell Res 220 (2): 357–62. doi:10.1006/excr.1995.1326. PMID 7556444. 
  2. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  3. ^ a b "Entrez Gene: KRT81 keratin 81". 

Further reading[edit]