MYO1G

MYO1G
Identifiers
Aliases	MYO1G, HA2, HLA-HA2, MHAG, myosin IG
External IDs	OMIM: 600642; MGI: 1927091; HomoloGene: 27996; GeneCards: MYO1G; OMA:MYO1G - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,979,088 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	6,470,965 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; thymus; ; blood; ; lymph node; ; cecum; ; appendix; ; spleen; ; pylorus; ; bone marrow cells;
	Top expressed in
	granulocyte; ; lymph node; ; mesenteric lymph nodes; ; spleen; ; tibiofemoral joint; ; thymus; ; bone marrow; ; blood; ; stroma of bone marrow; ; subcutaneous adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; calmodulin binding; phosphatidylinositol-3,4-bisphosphate binding; actin binding; phosphatidylinositol-4,5-bisphosphate binding; cytoskeletal motor activity; ATP binding; phosphatidylinositol-3,4,5-trisphosphate binding; lipid binding;
Cellular component	cell projection; membrane; filopodium; plasma membrane; microvillus; phagocytic cup; extracellular exosome; leading edge membrane; myosin complex; lamellipodium;
Biological process	T cell migration; T cell mediated immunity; adaptive immune response; Fc-gamma receptor signaling pathway involved in phagocytosis; cell gliding; immune system process; cell-substrate adhesion; phagocytosis; exocytosis; T cell meandering migration;
	Sources:Amigo / QuickGO
Orthologs
	64005
	246177
	ENSG00000136286
	ENSMUSG00000020437
	B0I1T2
	Q5SUA5
	NM_033054
	NM_178440
	NP_149043
	NP_848534
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin IG, also known as myosin 1G and MYO1G, is a protein that in humans is encoded by the MYO1G gene.^[5] MYO1G is a member of class I unconventional myosins. Its expression is highly restricted to hematopoietic tissues and cells. It localises exclusively to the plasma membrane and is dependent on both the motor domain and the tail domain.^[6] MYO1G regulates cell elasticity possibly by interaction plasma membrane and cortical actin in Jurkat T-cells.

Function

MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136286 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020437 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Myosin IG". Retrieved 24 December 2019.
^ Olety B, Wälte M, Honnert U, Schillers H, Bähler M (February 2010). "Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity". FEBS Letters. 584 (3): 493–9. doi:10.1016/j.febslet.2009.11.096. PMID 19968988. S2CID 27557093.,

Patino-Lopez G, Aravind L, Dong X, Kruhlak MJ, Ostap EM, Shaw S (March 2010). "Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH)". J. Biol. Chem. 285 (12): 8675–86. doi:10.1074/jbc.M109.086959. PMC 2838290. PMID 20071333.
Larsen ME, Kornblit B, Larsen MV, Masmas TN, Nielsen M, Thiim M, Garred P, Stryhn A, Lund O, Buus S, Vindelov L (October 2010). "Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation". Biol. Blood Marrow Transplant. 16 (10): 1370–81. doi:10.1016/j.bbmt.2010.03.022. PMID 20353833.
Lio HY, Tang JL, Wu J, Wu SJ, Lin CY, Yang YC (September 2010). "Minor histocompatibility antigen HA-1 and HA-2 polymorphisms in Taiwan: frequency and application in hematopoietic stem cell transplantation". Clin. Chem. Lab. Med. 48 (9): 1287–93. doi:10.1515/CCLM.2010.246. PMID 20509834. S2CID 32914575.
Sellami MH, Torjemane L, Espadas de Arias A, Kaabi H, Ladeb S, Ben Othman T, Poli F, Hmida S (2010). "Mismatch for the minor histocompatibility antigen HA-2 and GVHD occurrence in HLA-A*0201-positive Tunisian recipients of HSCs". Immunol. Invest. 39 (6): 611–20. doi:10.3109/08820131003775029. PMID 20653428. S2CID 38774267.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136286 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020437 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Myosin IG". Retrieved 24 December 2019.

[6] Olety B, Wälte M, Honnert U, Schillers H, Bähler M (February 2010). "Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity". FEBS Letters. 584 (3): 493–9. doi:10.1016/j.febslet.2009.11.096. PMID 19968988. S2CID 27557093.,

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Function

References

Further reading