3α-Dihydroprogesterone
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| Names | |
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| IUPAC name
3α-Hydroxy-4-pregnen-20-one
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| Other names
3α-Dihydroprogesterone
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C21H32O2 | |
| Molar mass | 316.47758 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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3α-Dihydroprogesterone (3α-DHP), also known as 3α-hydroxyprogesterone, as well as pregn-4-en-3α-ol-20-one, is an endogenous neurosteroid.[1] It is biosynthesized by 3α-hydroxysteroid dehydrogenase from progesterone.[1] 3α-DHP has been found to act as a positive allosteric modulator of the GABAA receptor and is described as being as active as allopregnanolone in regard to this action.[1] In accordance, it has anxiolytic effects in animals.[2] 3α-DHP has also been found to inhibit the secretion of follicle-stimulating hormone (FSH) from the rat pituitary gland, demonstrating possible antigonadotropic properties.[1] Unlike the case of most other inhibitory neurosteroids, 3α-DHP production is not blocked by 5α-reductase inhibitors like finasteride.[1]
See also
References
- ^ a b c d e Neurosteroids and Brain Function. Academic Press. 12 December 2001. pp. 484–. ISBN 978-0-08-054423-6.
- ^ Kavaliers, Martin; Wiebe, John P.; Galea, Liisa A.M. (1994). "Reduction of predator odor-induced anxiety in mice by the neurosteroid 3α-hydroxy-4-pregnen-20-one (3αHP)". Brain Research. 645 (1–2): 325–329. doi:10.1016/0006-8993(94)91667-5. ISSN 0006-8993.
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