Allosteric serotonin reuptake inhibitor

From Wikipedia, the free encyclopedia
Jump to: navigation, search

Allosteric serotonin reuptake inhibitor is a type of selective serotonin reuptake inhibitor (SSRI). Currently only escitalopram, the S stereoisomer of the SSRI citalopram is included in this category. It is based on the observation that the R isomer of citalopram can decrease the potency and inhibit the effects of the S isomer, probably through an allosteric interaction between two distinct, non-overlapping binding sites for the two different isomers on the serotonin transporter. Escitalopram, thus, binds not only to the primary site like any other SSRI, but also to the allosteric site.


  • Connie Sánchez (2006). "The Pharmacology of Citalopram Enantiomers: The Antagonism by R-Citalopram on the Effect of S-Citalopram". Basic & Clinical Pharmacology & Toxicology. 99 (2): 91–5. PMID 16918708. doi:10.1111/j.1742-7843.2006.pto_295.x.