Demoxepam
Appearance
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Pharmacokinetic data | |
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Elimination half-life | 35–40 hours |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.012.287 |
Chemical and physical data | |
Formula | C15H11ClN2O2 |
Molar mass | 286.713 g·mol−1 |
3D model (JSmol) | |
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Demoxepam[1] is a drug which is a benzodiazepine derivative. It is a metabolite of chlordiazepoxide and has anticonvulsant properties[2][3] and presumably other characteristic benzodiazepine properties.
Synthesis
Demoxepam is also an intermediate in the synthesis of oxazepam; it is also used in one of the syntheses of medazepam. It can be considered directly analogous/synonoymous with the synthesis of chlordiazepoxide, with the exception that instead of methylamine, hydroxide ion is the choice of base; here acid is not used for the cyclodehydration step though.
![](http://upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Demoxepam_synthesis.svg/700px-Demoxepam_synthesis.svg.png)
See also
References
- ^ US Patent 3136815
- ^ "nortetrazepam". psychotropics.dk. 2003. Retrieved 7 December 2009.
- ^ "LIST OF INTERNATIONAL NON-PROPRIETARY NAMES (INNS), PROVIDED FOR PHARMACEUTICAL SUBSTANCES BY THE WORLD HEALTH ORGANIZATION, WHICH ARE FREE OF DUTY" (PDF). Official Journal of the European Communities. eur-lex.europa.eu. 23 October 2001. Retrieved 7 December 2009.