Tropomodulin 4: Difference between revisions
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{{PBB|geneid=29765}} |
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{{protein |
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|Name=tropomodulin 4 (muscle) |
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|caption= |
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|image= |
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|width= |
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|HGNCid=11874 |
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|Symbol=TMOD4 |
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|AltSymbols= |
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|EntrezGene=29765 |
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|OMIM=605834 |
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|RefSeq= NM_013353 |
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|UniProt= Q9NZQ9 |
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|PDB= |
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|ECnumber= |
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|Chromosome=1 |
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|Arm=q |
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|Band=12 |
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|LocusSupplementaryData= |
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'''Tropomodulin 4 (muscle)''' also known as '''TMOD4''' is a [[protein]] which in humans is encoded by the ''TMOD4'' [[gene]].<ref name="pmid10662549">{{cite journal | author = Cox PR, Zoghbi HY | title = Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs | journal = Genomics | volume = 63 | issue = 1 | pages = 97–107 | year = 2000 | month = January | pmid = 10662549 | doi = 10.1006/geno.1999.6061 | url = | issn = }}</ref><ref name="pmid10497209">{{cite journal | author = Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM | title = Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle | journal = J. Biol. Chem. | volume = 274 | issue = 40 | pages = 28466–75 | year = 1999 | month = October | pmid = 10497209 | doi = | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=10497209 | issn = }}</ref> |
'''Tropomodulin 4 (muscle)''' also known as '''TMOD4''' is a [[protein]] which in humans is encoded by the ''TMOD4'' [[gene]].<ref name="pmid10662549">{{cite journal | author = Cox PR, Zoghbi HY | title = Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs | journal = Genomics | volume = 63 | issue = 1 | pages = 97–107 | year = 2000 | month = January | pmid = 10662549 | doi = 10.1006/geno.1999.6061 | url = | issn = }}</ref><ref name="pmid10497209">{{cite journal | author = Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM | title = Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle | journal = J. Biol. Chem. | volume = 274 | issue = 40 | pages = 28466–75 | year = 1999 | month = October | pmid = 10497209 | doi = | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=10497209 | issn = }}</ref> |
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== References == |
== References == |
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{{Reflist}} |
{{Reflist}} |
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==Further reading== |
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{{refbegin | 2}} |
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*{{cite journal |author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }} |
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*{{cite journal |author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} |
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*{{cite journal |author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }} |
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*{{cite journal |author=Cox PR, Siddique T, Zoghbi HY |title=Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4. |journal=BMC Genomics |volume=2 |issue= 1 |pages= 7 |year= 2001 |pmid= 11716785 |doi= }} |
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*{{cite journal |author=McElhinny AS, Kolmerer B, Fowler VM, ''et al.'' |title=The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 583-92 |year= 2001 |pmid= 11016930 |doi= 10.1074/jbc.M005693200 }} |
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{{refend}} |
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{{NLM content}} |
{{NLM content}} |
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Revision as of 12:18, 21 March 2010
Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the TMOD4 gene.[1][2]
Function
This gene encodes a muscle-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.[3]
References
- ^ Cox PR, Zoghbi HY (2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM (1999). "Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle". J. Biol. Chem. 274 (40): 28466–75. PMID 10497209.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: TMOD4 , Tropomodulin 4 (muscle)".
Further reading
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Cox PR, Siddique T, Zoghbi HY (2001). "Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4". BMC Genomics. 2 (1): 7. PMID 11716785.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - McElhinny AS, Kolmerer B, Fowler VM; et al. (2001). "The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments". J. Biol. Chem. 276 (1): 583–92. doi:10.1074/jbc.M005693200. PMID 11016930.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
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