Dimethocaine: Difference between revisions
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'''Dimethocaine''', also known as '''larocaine''', is a [[local anesthetic]] with [[stimulant]] properties nearly as potent as [[cocaine]].<ref>{{cite journal |author=Woodward JJ, Compton DM, Balster RL, Martin BR |title=In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter |journal=Eur. J. Pharmacol. |volume=277 |issue=1 |pages=7–13 |year=1995 |month=April |pmid=7635175 |doi= 10.1016/0014-2999(95)00042-J|url=http://linkinghub.elsevier.com/retrieve/pii/001429999500042J}}</ref><ref>Rigon AR, Takahashi RN. Stimulant activities of dimethocaine in mice: reinforcing and anxiogenic effects. ''Psychopharmacology (Berlin)''. 1996 Oct;127(4):323-7. PMID 8923567</ref><ref name=Wilcox>Wilcox KM, Kimmel HL, Lindsey KP, Votaw JR, Goodman MM, Howell LL. In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. ''Synapse''. 2005 Dec 15;58(4):220-8. PMID 16206183 [http://research.yerkes.emory.edu/Howell/Synapse58.pdf PDF]</ref> |
'''Dimethocaine''', also known as '''larocaine''', is a [[local anesthetic]] with [[stimulant]] properties nearly as potent as [[cocaine]].<ref>{{cite journal |author=Woodward JJ, Compton DM, Balster RL, Martin BR |title=In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter |journal=Eur. J. Pharmacol. |volume=277 |issue=1 |pages=7–13 |year=1995 |month=April |pmid=7635175 |doi= 10.1016/0014-2999(95)00042-J|url=http://linkinghub.elsevier.com/retrieve/pii/001429999500042J}}</ref><ref>Rigon AR, Takahashi RN. Stimulant activities of dimethocaine in mice: reinforcing and anxiogenic effects. ''Psychopharmacology (Berlin)''. 1996 Oct;127(4):323-7. PMID 8923567</ref><ref name=Wilcox>Wilcox KM, Kimmel HL, Lindsey KP, Votaw JR, Goodman MM, Howell LL. In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. ''Synapse''. 2005 Dec 15;58(4):220-8. PMID 16206183 [http://research.yerkes.emory.edu/Howell/Synapse58.pdf PDF]</ref> |
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In actual fact, according to the last reference, although Dimethocaine is ~ cocaine as a [[local anesthetic]], in order to achieve a DAT occupancy that evokes "euphoria" the dose needed to be taken is ten times greater than for cocaine.<ref name=Wilcox/> |
In actual fact, according to the last reference, although Dimethocaine is ~ cocaine as a [[local anesthetic]], in order to achieve a DAT occupancy that evokes "euphoria" (DAT occupancy ≥ 65%)<ref>Howell, L.L. and Wilcox, K.M. The dopamine transporter and cocaine medication development: Drug self-administration in nonhuman primates. JPET, 298: 1-6, 2001. [http://research.yerkes.emory.edu/Howell/JPET298.pdf PDF]</ref> the dose needed to be taken is ten times greater than for cocaine.<ref name=Wilcox/> |
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==See also== |
==See also== |
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Revision as of 16:27, 11 August 2009
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| Formula | C16H26N2O2 |
| Molar mass | 278.39 g·mol−1 |
Dimethocaine, also known as larocaine, is a local anesthetic with stimulant properties nearly as potent as cocaine.[1][2][3]
In actual fact, according to the last reference, although Dimethocaine is ~ cocaine as a local anesthetic, in order to achieve a DAT occupancy that evokes "euphoria" (DAT occupancy ≥ 65%)[4] the dose needed to be taken is ten times greater than for cocaine.[3]
See also
References
- ^ Woodward JJ, Compton DM, Balster RL, Martin BR (1995). "In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter". Eur. J. Pharmacol. 277 (1): 7–13. doi:10.1016/0014-2999(95)00042-J. PMID 7635175.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Rigon AR, Takahashi RN. Stimulant activities of dimethocaine in mice: reinforcing and anxiogenic effects. Psychopharmacology (Berlin). 1996 Oct;127(4):323-7. PMID 8923567
- ^ a b Wilcox KM, Kimmel HL, Lindsey KP, Votaw JR, Goodman MM, Howell LL. In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. Synapse. 2005 Dec 15;58(4):220-8. PMID 16206183 PDF
- ^ Howell, L.L. and Wilcox, K.M. The dopamine transporter and cocaine medication development: Drug self-administration in nonhuman primates. JPET, 298: 1-6, 2001. PDF
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