Nitromethaqualone
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Formula | C16H13N3O4 |
Molar mass | 311.29 g·mol−1 |
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Nitromethaqualone[1] is an analogue of methaqualone that has similar sedative and hypnotic properties.[2] It is significantly more potent (10x) compared to the parent compound; the typical dose is approximately 25 mg.[3] However, the aromatic nitro group is metabolised to the corresponding aniline, which proved to be a mutagen.[3] As a consequence, nitromethaqualone was not developed further due to toxicity concerns.
References
- ^ US patent 3162634, Klosa J (Berlin, Germany), "2-Methyl-3-(2'-methyl-3'-chlorphenyl)-quinazolone-(4)", issued 1964-12-22
- ^ Szirmai A (November 1963). "[Pharmacological and Therapeutic Studies with a New Quinazolone Derivative, Nitromethaqualone]". Therapeutische Umschau. Revue Therapeutique (in German). 20: 542–6. PMID 14101319.
- ^ a b Van Boven M, Daenens P (October 1982). "Biotransformation and excretion of nitromethaqualone in rats and humans". Journal of Pharmaceutical Sciences. 71 (10): 1152–7. doi:10.1002/jps.2600711019. PMID 7143214.
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