Bexlosteride
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| Other names | LY 300502 |
| Routes of administration | Oral |
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| Formula | C14H16ClNO |
| Molar mass | 249.74 g·mol−1 |
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Bexlosteride is a potent and noncompetitive inhibitor of the enzyme 5α-reductase related to finasteride and dutasteride.[1][2] It is selective for the type I isoform of the enzyme.[1] It advanced to Phase III clinical trials, but development was halted at that stage, and it was never marketed.[3][4]
See also
References
- ^ a b Chang C (2002). Androgens and androgen receptor : mechanisms, functions, and clinical application. Boston: Kluwer Academic Publishers. ISBN 1-4020-7188-4.
- ^ Lednicer D (2008). Strategies for Organic Drug Synthesis and Design. New York: Wiley-Interscience. ISBN 978-0-470-19039-5.
- ^ "Drug Profile: Bexlosteride". Adis Insight.
- ^ Reaxys entry for bexlosteride: Reaxys Registry Number: 6635310
Drugs used in benign prostatic hyperplasia (G04C) | |
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| 5α-Reductase inhibitors | |
| Alpha-1 blockers | |
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