CXCL13

CXCL13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZAI, 5CBA, 5CBE
Identifiers
Aliases	CXCL13, ANGIE, ANGIE2, BCA-1, BCA1, BLC, BLR1L, SCYB13, C-X-C motif chemokine ligand 13
External IDs	OMIM: 605149; MGI: 1888499; HomoloGene: 48431; GeneCards: CXCL13; OMA:CXCL13 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	77,611,834 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	96,108,927 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; appendix; ; mucosa of ileum; ; epithelium of nasopharynx; ; rectum; ; periodontal fiber; ; tonsil; ; superficial temporal artery; ; decidua;
	Top expressed in
	spleen; ; mesenteric lymph nodes; ; migratory enteric neural crest cell; ; morula; ; submandibular gland; ; tunica adventitia of aorta; ; subcutaneous adipose tissue; ; Paneth cell; ; white adipose tissue; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	receptor ligand activity; CCR10 chemokine receptor binding; cytokine activity; heparin binding; CXCR3 chemokine receptor binding; chemokine activity; protein heterodimerization activity; fibroblast growth factor binding; CXCR5 chemokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	chemokine-mediated signaling pathway; positive regulation of cytosolic calcium ion concentration; cell-cell signaling; germinal center formation; regulation of angiogenesis; chemotaxis; endothelial cell chemotaxis to fibroblast growth factor; regulation of humoral immune response; cell surface receptor signaling pathway; response to lipopolysaccharide; regulation of cell population proliferation; defense response to bacterium; negative regulation of endothelial cell chemotaxis to fibroblast growth factor; positive regulation of T cell chemotaxis; immune response; inflammatory response; chronic inflammatory response; defense response; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; lymphocyte chemotaxis across high endothelial venule; positive regulation of integrin activation; positive regulation of cell-cell adhesion mediated by integrin; B cell chemotaxis; activation of GTPase activity; neutrophil chemotaxis; leukocyte chemotaxis; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	10563
	55985
	ENSG00000156234
	ENSMUSG00000023078
	O43927
	O55038
	NM_006419; NM_001371558
	NM_018866
	NP_006410; NP_001358487
	NP_061354
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene.^[5]^[6]

Function

CXCL13 is a small chemokine belonging to the CXC chemokine family. As its other names suggest, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5.^[5]^[7] CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues^[8] and is expressed highly in the liver, spleen, lymph nodes, and gut of humans.^[5] The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines.^[6]

In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or T_FH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as angioimmunoblastic T-cell lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156234 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023078 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (February 1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416.
^ ^a ^b Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (February 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. Bibcode:1998Natur.391..799G. doi:10.1038/35876. PMID 9486651. S2CID 4373691.
^ Ansel KM, Harris RB, Cyster JG (January 2002). "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity". Immunity. 16 (1): 67–76. doi:10.1016/S1074-7613(01)00257-6. PMID 11825566.
^ Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG (July 2000). "A chemokine-driven positive feedback loop organizes lymphoid follicles". Nature. 406 (6793): 309–14. doi:10.1038/35018581. PMID 10917533. S2CID 4369622.
^ de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (June 2007). "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells". Blood. 109 (11): 4952–63. doi:10.1182/blood-2006-10-055145. PMID 17284527.

External links

Human CXCL13 genome location and CXCL13 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: O43927 (C-X-C motif chemokine 13) at the PDBe-KB.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156234 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023078 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9463416-5] Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (February 1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416.

[pmid9486651-6] Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (February 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. Bibcode:1998Natur.391..799G. doi:10.1038/35876. PMID 9486651. S2CID 4373691.

[pmid11825566-7] Ansel KM, Harris RB, Cyster JG (January 2002). "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity". Immunity. 16 (1): 67–76. doi:10.1016/S1074-7613(01)00257-6. PMID 11825566.

[pmid10917533-8] Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG (July 2000). "A chemokine-driven positive feedback loop organizes lymphoid follicles". Nature. 406 (6793): 309–14. doi:10.1038/35018581. PMID 10917533. S2CID 4369622.

[pmid17284527-9] Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (June 2007). "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells". Blood. 109 (11): 4952–63. doi:10.1182/blood-2006-10-055145. PMID 17284527.

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