Prolactin receptor
| prolactin receptor | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PRLR | ||||||
| NCBI gene | 5618 | ||||||
| HGNC | 9446 | ||||||
| OMIM | 176761 | ||||||
| PDB | 1RW5 | ||||||
| RefSeq | NM_000949 | ||||||
| UniProt | P16471 | ||||||
| Other data | |||||||
| Locus | Chr. 5 p13-p12 | ||||||
| |||||||
The prolactin receptor—encoded by a gene on Chromosome 5p13-14—interacts with the prolactin molecule as a transmembrane receptor.
Thus it contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region.
The receptor is a cytokine receptor,[1] and second messenger cascades include the JAK-STAT pathway, JAK-RUSH pathway,[2][3] Ras-Raf-MAPK, and PI-3K.[4]
There may be variation among different tissue prolactin receptors.[5]
References
- ^ Prolactin: The multi-faceted potentiator of mammary growth and function. Trott JF, Schennink A, Petrie WK, Manjarin R, Vanklompenberg MK, Hovey RC. J Anim Sci. 2011 Dec 28.
- ^ Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling. Helmer RA, Panchoo M, Dertien JS, Bhakta SM, Hewetson A, Chilton BS. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):143-9.
- ^ Prolactin induces Jak2 phosphorylation of RUSHY195. Helmer RA, Dertien JS, Chilton BS. Mol Cell Endocrinol. 2011 May 16;338(1-2):79-83.
- ^ The role of prolactin in mammary carcinoma. Clevenger CV, Furth PA, Hankinson SE, Schuler LA. Endocr Rev. 2003 Feb;24(1):1-27.
- ^ Impact of prolactin receptor isoforms on reproduction. Binart N, Bachelot A, Bouilly J. Trends Endocrinol Metab. 2010 Jun;21(6):362-8.
External links
- Prolactin+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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