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ORG-25435 is a synthetic drug developed by Organon International , which acts as a GABAA receptor positive allosteric modulator , and produces sedative effects. It has been researched for use as an intravenous anesthetic agent, with positive results in initial trials, although negative side effects like hypotension and tachycardia , as well as unpredictable pharmacokinetics at higher doses, have meant it has ultimately not been adopted for medical use.[ 1] [ 2]
References
^ Anderson A, Belelli D, Bennett DJ, Buchanan KI, Casula A, Cooke A, et al. (October 2001). "Alpha-amino acid phenolic ester derivatives: novel water-soluble general anesthetic agents which allosterically modulate GABA(A) receptors". Journal of Medicinal Chemistry . 44 (22): 3582–91. doi :10.1021/jm010903i . PMID 11606122 . ^ Rigby-Jones AE, Sneyd JR, Vijn P, Boen P, Cross M (June 2010). "First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial" . BMC Anesthesiology . 10 : 10. doi :10.1186/1471-2253-10-10 PMC 2914736 PMID 20587019 .
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