Climazolam

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Climazolam
Clinical data
Trade namesClimasol
AHFS/Drugs.comInternational Drug Names
ATCvet code
Legal status
Legal status
Identifiers
  • 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H13Cl2N3
Molar mass342.22 g·mol−1
3D model (JSmol)
  • ClC1=CC=CC=C1C2=NCC3=CN=C(C)N3C4=C2C=C(C=C4)Cl

Climazolam[1] (Ro21-3982) was introduced under licence as a veterinary medicine by the Swiss Pharmaceutical company Gräub under the tradename Climasol.[2] Climazolam is a benzodiazepine, specifically an imidazobenzodiazepine derivative developed by Hoffman-LaRoche. It is similar in structure to midazolam and diclazepam and is used in veterinary medicine for anesthetizing animals.[3][4]

References

  1. ^ US 4280957 - Imidazodiazepines and processes therefor
  2. ^ https://www.drugs.com/international/climazolam.html
  3. ^ Ganter M, Kanngiesser M (Aug 1991). "Effect of ketamine and its combinations with xylazine and climazolam on the circulation and respiration in swine". Zentralbl Veterinarmed A (in German). 38 (7): 501–509. PMID 1950241.
  4. ^ Bettschart-Wolfensberger R, Taylor PM, Sear JW, Bloomfield MR, Rentsch K, Dawling S (Oct 1996). "Physiologic effects of anesthesia induced and maintained by intravenous administration of a climazolam-ketamine combination in ponies premedicated with acepromazine and xylazine". American Journal of Veterinary Research. 57 (10): 1472–1477. PMID 8896687.