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Diosgenin

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Diosgenin
Names
IUPAC name
(3β,25R)-spirost-5-en-3-ol
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.007.396 Edit this at Wikidata
EC Number
  • 208-134-3
UNII
  • InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1 checkY
    Key: WQLVFSAGQJTQCK-VKROHFNGSA-N checkY
  • InChI=1/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1
    Key: WQLVFSAGQJTQCK-VKROHFNGBS
  • O1[C@@H]4[C@H]([C@@H]([C@]12OC[C@@H](CC2)C)C)[C@@]5(C)CC[C@@H]3[C@@]6(C(=C/C[C@H]3[C@@H]5C4)\C[C@@H](O)CC6)C
Properties
C27H42O3
Molar mass 414.630 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Diosgenin, a phytosteroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam, such as the Kokoro. The sugar-free (aglycone) product of such hydrolysis, diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone, and other steroid products.

Sources

It is present in detectable amounts in Costus speciosus, Smilax menispermoidea, species of Paris, Aletris, Trigonella, and Trillium, and in extractable amounts many species of Dioscorea – D. althaeoides, colletti, composita[1], floribunda, futschauensis, gracillima, hispida, hypoglauca, mexicana[2], nipponica, panthaica, parviflora, septemloba, and zingiberensis.[3]

Industrial uses

Diosgenin is a precursor for several hormones, starting with the Marker degradation process, which includes synthesis of progesterone.[4] The process was used in the early manufacturing of combined oral contraceptive pills.[5]

References

  1. ^ "Dioscorea composita". Germplasm Resources Information Network. Agricultural Research Service, United States Department of Agriculture. Retrieved 2008-09-14.
  2. ^ "Dioscorea mexicana". Germplasm Resources Information Network. Agricultural Research Service, United States Department of Agriculture. Retrieved 2008-09-14.
  3. ^ "2950 Diosgenin". Retrieved 2007-05-29.[permanent dead link]
  4. ^ Marker RE, Krueger J (1940). "Sterols. CXII. Sapogenins. XLI. The Preparation of Trillin and its Conversion to Progesterone". J. Am. Chem. Soc. 62 (12): 3349–3350. doi:10.1021/ja01869a023.
  5. ^ Djerassi C (December 1992). "Steroid research at Syntex: "the pill" and cortisone". Steroids. 57 (12): 631–41. doi:10.1016/0039-128X(92)90016-3. PMID 1481227.
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