Alfaxolone/alfadolone
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(Redirected from Althesin)
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| Alfaxalone | anesthetic |
| Alfadolone | anesthetic |
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Alfaxolone/alfadolone (Althesin) is a short acting intravenous anaesthetic agent, now withdrawn from the market due to severe drug reactions. It is composed of a mixture of alfaxalone and alfadolone, two neurosteroids.
Cremophor EL (aka. Polyoxyl 35 Castor Oil, a surfactant and derivative of castor oil) was the solubilizing agent (excipient / additive) of Althesin. [1]
A study 2001 found that Cremophor EL , when previously used as a solubilizing agent in lipid emulsions, was responsible for severe anaphylactoid reactions. Drugs using it were reformulated to use other emulsifiers. [2]
Alfaxolone/alfadolone has been re-branded as "Saffan" and is available for use in veterinary anaesthesia. [3] [4]
[edit] References
- ^ Clarke, R. S.; Dundee, J. W.; Carson, I. W. (1973). "A new steroid anaesthetic-Althesin". Proceedings of the Royal Society of Medicine 66 (10): 1027–1030. PMC 1645602. PMID 4148526. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1645602.
- ^ MacPherson, R. D. (2001). "Pharmaceutics for the anaesthetist". Anaesthesia 56 (10): 965–979. PMID 11576099.
- ^ Dyson, D. H.; Allen, D. G.; Ingwersen, W.; Pascoe, P. J.; O'Grady, M. (1987). "Effects of Saffan on cardiopulmonary function in healthy cats". Canadian journal of veterinary research 51 (2): 236–239. PMC 1255310. PMID 3111675. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1255310.
- ^ Nadeson, R.; Goodchild, C. S. (2001). "Antinociceptive properties of neurosteroids III: Experiments with alphadolone given intravenously, intraperitoneally, and intragastrically". British journal of anaesthesia 86 (5): 704–708. PMID 11575348. http://www.anesthesia-analgesia.org/content/97/3/798.full.
