PKP2

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Plakophilin 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PKP2 ; ARVD9
External IDs OMIM602861 MGI1914701 HomoloGene3364 GeneCards: PKP2 Gene
RNA expression pattern
PBB GE PKP2 207717 s at tn.png
PBB GE PKP2 214154 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5318 67451
Ensembl ENSG00000057294 ENSMUSG00000041957
UniProt Q99959 E0CX59
RefSeq (mRNA) NM_001005242 NM_026163
RefSeq (protein) NP_001005242 NP_080439
Location (UCSC) Chr 12:
32.94 – 33.05 Mb
Chr 16:
16.21 – 16.27 Mb
PubMed search [1] [2]

Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene.[1][2]

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.[2]

Interactions[edit]

PKP2 has been shown to interact with Desmoplakin,[3] Plakoglobin[3] and Desmoglein 1.[3]

See also[edit]

References[edit]

  1. ^ Mertens C, Kuhn C, Franke WW (Jan 1997). "Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque". J Cell Biol 135 (4): 1009–25. doi:10.1083/jcb.135.4.1009. PMC 2133394. PMID 8922383. 
  2. ^ a b "Entrez Gene: PKP2 plakophilin 2". 
  3. ^ a b c Chen, Xinyu; Bonne Stefan; Hatzfeld Mechthild; van Roy Frans; Green Kathleen J (Mar 2002). "Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling". J. Biol. Chem. (United States) 277 (12): 10512–22. doi:10.1074/jbc.M108765200. ISSN 0021-9258. PMID 11790773. 

Further reading[edit]

External links[edit]