GNA12

GNA12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZCA
Identifiers
Aliases	GNA12, NNX3, RMP, gep, G protein subunit alpha 12, HG1M1
External IDs	OMIM: 604394; MGI: 95767; HomoloGene: 22398; GeneCards: GNA12; OMA:GNA12 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	2,844,308 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	140,816,186 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; stromal cell of endometrium; ; internal globus pallidus; ; C1 segment; ; amygdala; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; substantia nigra; ; right coronary artery;
	Top expressed in
	right kidney; ; myocardium of ventricle; ; ventricular zone; ; interventricular septum; ; zygote; ; stroma of bone marrow; ; cardiac muscle tissue of left ventricle; ; molar; ; right ventricle; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; metal ion binding; protein binding; guanyl nucleotide binding; G protein-coupled receptor binding; D5 dopamine receptor binding; signal transducer activity; G-protein beta/gamma-subunit complex binding; GTPase activity;
Cellular component	membrane; focal adhesion; heterotrimeric G-protein complex; brush border membrane; cytoplasm; plasma membrane; lateral plasma membrane;
Biological process	cell differentiation; intracellular signal transduction; regulation of TOR signaling; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; small GTPase mediated signal transduction; embryonic digit morphogenesis; blood coagulation; in utero embryonic development; platelet activation; regulation of cell shape; regulation of proteasomal ubiquitin-dependent protein catabolic process; signal transduction; G protein-coupled receptor signaling pathway; regulation of fibroblast migration; Rho protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2768
	14673
	ENSG00000146535
	ENSMUSG00000000149
	Q03113
	P27600
	NM_001282440; NM_001282441; NM_001293092; NM_007353
	NM_010302
	NP_001269369; NP_001269370; NP_001280021; NP_031379
	NP_034432
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.^[5]^[6]^[7]

Interactions

GNA12 has been shown to interact with ARHGEF1,^[8] PPP5C,^[9] ARHGEF12,^[10]^[11] Heat shock protein 90kDa alpha (cytosolic), member A1^[12] and TEC.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146535 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000149 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Molecular and Cellular Biology. 13 (2): 762–8. PMC 358958. PMID 8423800.
^ Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene. 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467.
^ "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12".
^ Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.
^ Yamaguchi Y, Katoh H, Mori K, Negishi M (August 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367.
^ Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters. 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164.
^ ^a ^b Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
^ Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA (December 2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". The Journal of Biological Chemistry. 276 (49): 46088–93. doi:10.1074/jbc.M108711200. PMID 11598136.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links

GNA12+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146535 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000149 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8423800-5] Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Molecular and Cellular Biology. 13 (2): 762–8. PMC 358958. PMID 8423800.

[pmid16247467-6] Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene. 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467.

[entrez-7] "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12".

[pmid14634662-8] Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.

[pmid12176367-9] Yamaguchi Y, Katoh H, Mori K, Negishi M (August 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367.

[pmid11094164-10] Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters. 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164.

[pmid12515866-11] Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.

[pmid11598136-12] Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA (December 2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". The Journal of Biological Chemistry. 276 (49): 46088–93. doi:10.1074/jbc.M108711200. PMID 11598136.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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Interactions

See also

References

External links