IL36A

IL36A
Identifiers
Aliases	IL36A, FIL1, FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6, interleukin 36, alpha, interleukin 36 alpha
External IDs	OMIM: 605509; MGI: 1859324; HomoloGene: 8688; GeneCards: IL36A; OMA:IL36A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	113,008,044 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	24,115,714 bp
RNA expression pattern
	Top expressed in
	epithelium of esophagus; ; testicle; ; oral cavity; ; mucosa of pharynx; ; body of tongue; ; pancreatic ductal cell; ; buccal mucosa cell; ; gums; ; tonsil; ; vagina;
	Top expressed in
	esophagus; ; lip; ; cervix; ; right ventricle; ; skin of external ear; ; umbilical cord; ; tibiofemoral joint; ; lumbar subsegment of spinal cord; ; temporal muscle; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-1 receptor binding; cytokine activity;
Cellular component	extracellular region; extracellular space;
Biological process	positive regulation of interleukin-6 production; innate immune response; positive regulation of cytokine production; immune system process; inflammatory response; immune response; regulation of signaling receptor activity; cytokine-mediated signaling pathway; neutrophil chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of JNK cascade; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	27179
	54448
	ENSG00000136694
	ENSMUSG00000026984
	Q9UHA7
	Q9JLA2
	NM_014440
	NM_019450
	NP_055255
	NP_062323
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-36 alpha also known as interleukin-1 family member 6 (IL1F6) is a protein that in humans is encoded by the IL36A gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136694 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026984 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem. 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: IL1F6 interleukin 1 family, member 6 (epsilon)".

Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382–4. doi:10.1006/geno.1994.1076. PMID 8188271.
Nothwang HG; Strahm B; Denich D; et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13". Genomics. 41 (3): 370–8. doi:10.1006/geno.1997.4654. PMID 9169134. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Mulero JJ; Pace AM; Nelken ST; et al. (1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem. Biophys. Res. Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Kumar S; McDonnell PC; Lehr R; et al. (2000). "Identification and initial characterization of four novel members of the interleukin-1 family". J. Biol. Chem. 275 (14): 10308–14. doi:10.1074/jbc.275.14.10308. PMID 10744718. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
Busfield SJ; Comrack CA; Yu G; et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics. 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Barton JL; Herbst R; Bosisio D; et al. (2001). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities". Eur. J. Immunol. 30 (11): 3299–308. doi:10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S. PMID 11093146. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Pan G; Risser P; Mao W; et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp". Cytokine. 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID 11145836. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Lin H; Ho AS; Haley-Vicente D; et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
Debets R; Timans JC; Homey B; et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". J. Immunol. 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Sims JE; Nicklin MJ; Bazan JF; et al. (2001). "A new nomenclature for IL-1-family genes". Trends Immunol. 22 (10): 536–7. doi:10.1016/S1471-4906(01)02040-3. PMID 11574262. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Nicklin MJ; Barton JL; Nguyen M; et al. (2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics. 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Garnero P; Borel O; Sornay-Rendu E; et al. (2003). "Association between a functional interleukin-6 gene polymorphism and peak bone mineral density and postmenopausal bone loss in women: the OFELY study". Bone. 31 (1): 43–50. doi:10.1016/S8756-3282(02)00810-4. PMID 12110411. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Towne JE; Garka KE; Renshaw BR; et al. (2004). "Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs". J. Biol. Chem. 279 (14): 13677–88. doi:10.1074/jbc.M400117200. PMID 14734551. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Hillier LW; Graves TA; Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
Blumberg H; Dinh H; Trueblood ES; et al. (2007). "Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation". J. Exp. Med. 204 (11): 2603–14. doi:10.1084/jem.20070157. PMC 2118475. PMID 17908936. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136694 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026984 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10625660-5] Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem. 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[entrez-6] "Entrez Gene: IL1F6 interleukin 1 family, member 6 (epsilon)".

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References

Further reading