Interleukin 19
Interleukin 19 (IL19) is a protein that in humans is encoded by the IL19 gene.[5]
Function
The protein encoded by this gene is a cytokine that belongs to the IL-10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the interleukin-20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.[5]
Interleukin-19 is a cytokine that belongs to the IL-10 family of cytokines along with several other interleukins including IL-10, IL-20, IL-22, IL-24, IL-26, and several virus-encoded cytokines. It signals through the same cell surface receptor (IL-20R) that is used by IL-20 and IL-24. The IL-19 gene is expressed in resting monocytes and B cells. It is up-regulated in monocytes following stimulation with granulocyte-macrophage colony-stimulating factor (GM-CSF), lipopolysaccharide, or Pam3CSK4.[6] and [7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000142224 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016524 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Interleukin 19".
- ^ Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A (Jan 2003). "Crystal structure of interleukin-19 defines a new subfamily of helical cytokines". The Journal of Biological Chemistry. 278 (5): 3308–13. doi:10.1074/jbc.M208602200. PMID 12403790.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Kragstrup TW, Andersen T, Holm C, Schiøttz-Christensen B, Jurik AG, Hvid M, Deleuran B (May 2015). "Toll-like receptor 2 and 4 induced interleukin-19 dampens immune reactions and associates inversely with spondyloarthritis disease activity". Clinical and Experimental Immunology. 180 (2): 233–42. doi:10.1111/cei.12577. PMID 25639337.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This immunology article is a stub. You can help Wikipedia by expanding it. |