Topilutamide

Topilutamide
Clinical data
Trade names	Eucapil
Routes of; administration	Topical
Identifiers
	IUPAC name 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-[(2,2,2-trifluoroacetyl)amino]propanamide;
CAS Number	260980-89-0;
PubChem CID	44147451;
ChemSpider	8106619;
ECHA InfoCard	100.245.367
Chemical and physical data
Formula	C13H11F6N3O5
Molar mass	403.233959 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(CNC(=O)C(F)(F)F)(C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F)O;
	InChI InChI=1S/C13H11F6N3O5/c1-11(25,5-20-10(24)13(17,18)19)9(23)21-6-2-3-8(22(26)27)7(4-6)12(14,15)16/h2-4,25H,5H2,1H3,(H,20,24)(H,21,23)/t11-/m1/s1; Key:YCNCRLKXSLARFT-LLVKDONJSA-N;

Topilutamide (INN), known more commonly as fluridil (brand name Eucapil), is a topical non-steroidal antiandrogen marketed by Interpharma Praha which is used in a number of European countries in the treatment of androgenic alopecia.^[1]^[2]^[3]^[4]^[5] Sold as Eucapil, it is available as a 2% topical formulation intended for application to the scalp.^[4]

References

^ Sovak M, Seligson AL, Kucerova R, Bienova M, Hajduch M, Bucek M (2002). "Fluridil, a rationally designed topical agent for androgenetic alopecia: first clinical experience". Dermatol Surg. 28 (8): 678–85. doi:10.1046/j.1524-4725.2002.02017.x. PMID 12174057.
^ Robert S. Haber; Dowling Bluford Stough (2006). Hair Transplantation. Elsevier Health Sciences. pp. 7–. ISBN 1-4160-3104-9.
^ Scripta Medica. 2006. pp. 45, 53–54.
^ ^a ^b Marc R. Avram; Nicole E. Rogers (30 November 2009). Hair Transplantation. Cambridge University Press. pp. 11–. ISBN 978-1-139-48339-1.
^ Roger S. Kirby; Culley C. Carson; Michael G. Kirby (29 January 2009). Men's Health, Third Edition. CRC Press. pp. 362–. ISBN 978-1-4398-0807-8. {{cite book}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

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[pmid12174057-1] Sovak M, Seligson AL, Kucerova R, Bienova M, Hajduch M, Bucek M (2002). "Fluridil, a rationally designed topical agent for androgenetic alopecia: first clinical experience". Dermatol Surg. 28 (8): 678–85. doi:10.1046/j.1524-4725.2002.02017.x. PMID 12174057.

[HaberStough2006-2] Robert S. Haber; Dowling Bluford Stough (2006). Hair Transplantation. Elsevier Health Sciences. pp. 7–. ISBN 1-4160-3104-9.

[ScriptaMedica2006-3] Scripta Medica. 2006. pp. 45, 53–54.

[AvramRogers2009-4] Marc R. Avram; Nicole E. Rogers (30 November 2009). Hair Transplantation. Cambridge University Press. pp. 11–. ISBN 978-1-139-48339-1.

[KirbyCarson2009-5] Roger S. Kirby; Culley C. Carson; Michael G. Kirby (29 January 2009). Men's Health, Third Edition. CRC Press. pp. 362–. ISBN 978-1-4398-0807-8. {{cite book}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

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v t e Other dermatological preparations (D11)
Anti-seborrheics	Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Antifungals Bifonazole Cetrimonium bromide (cetrimide) Ciclopirox olamine (ciclopirox) Climbazole Clotrimazole Ketoconazole Miconazole Piroctone olamine Selenium disulfide (selenium sulfide) Xenysalate Zinc pyrithione (pyrithione zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea (urea-containing cream) Lithium salts Lithium gluconate Lithium succinate Topical corticosteroids (e.g., hydrocortisone)
Skin lightening	Hydroquinone Mequinol Monobenzone
Skin darkening	Afamelanotide Melanotan II
Anti-inflammatories	Alitretinoin Gamolenic acid Oxaceprol Pimecrolimus Tacrolimus Topical corticosteroids (e.g., hydrocortisone)
Alopecia treatments	5α-Reductase inhibitors Alfatradiol Dutasteride Finasteride Saw palmetto extract Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Topilutamide (fluridil) Potassium channel openers Minoxidil Others Nepidermin Ritlecitinib
Hair growth inhibitors	5α-Reductase inhibitors Dutasteride Finasteride Antiandrogens Bicalutamide Cyproterone acetate Flutamide Spironolactone Eflornithine
Others	Abrocitinib Aminobenzoate potassium Androgens (e.g., testosterone) Benzoylperoxide Brimonidine Caffeine Calcium gluconate Collagen Crisaborole Cromoglicic acid Delgocitinib Deoxycholic acid Diclofenac Dupilumab Estrogens (e.g., estradiol) Glycopyrronium bromide Glycopyrronium tosylate Hyaluronic acid Hydrogen peroxide Ivermectin Lebrikizumab Lokivetmab Magnesium sulfate Metandienone Nemolizumab Oclacitinib Oxymetazoline Povidone-iodine Pregnenolone acetate Progestogens (e.g., progesterone) Ruxolitinib Tiratricol Tralokinumab

See also

References