Solute carrier organic anion transporter family member 2A1
Template:PBB Solute carrier organic anion transporter family, member 2A1 also known as the prostaglandin transporter (PGT) is a protein that in humans is encoded by the SLCO2A1 gene.[1]
This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning organic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.[1]
Clinical relevance
Mutations in this gene have been shown to cause primary hypertrophic osteoarthropathy.[2]
References
- ^ a b "Entrez Gene: Solute carrier organic anion transporter family, member 2A1". Retrieved 2011-12-30.
- ^ Zhang Z, Xia W, He J, Zhang Z, Ke Y, Yue H, Wang C, Zhang H, Gu J, Hu W, Fu W, Hu Y, Li M, Liu Y (December 2011). "Exome Sequencing Identifies SLCO2A1 Mutations as a Cause of Primary Hypertrophic Osteoarthropathy". Am J Hum Genet. 90 (1): 125–32. doi:10.1016/j.ajhg.2011.11.019. PMID 22197487.
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Further reading
- Hagenbuch, B.; Meier, P. J. (2004). "Organic anion transporting polypeptides of the OATP/ SLC21 family: Phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties". Pfl�gers Archiv European Journal of Physiology. 447 (5): 653–665. doi:10.1007/s00424-003-1168-y. PMID 14579113.
{{cite journal}}: replacement character in|journal=at position 4 (help) - Huang, C. S.; Huang, M. J.; Lin, M. S.; Yang, S. S.; Teng, H. C.; Tang, K. S. (2005). "Genetic factors related to unconjugated hyperbilirubinemia amongst adults". Pharmacogenetics and genomics. 15 (1): 43–50. doi:10.1097/01213011-200501000-00007. PMID 15864125.
- Kang, J.; Chapdelaine, P.; Laberge, P. Y.; Fortier, M. A. (2005). "Functional characterization of prostaglandin transporter and terminal prostaglandin synthases during decidualization of human endometrial stromal cells". Human Reproduction. 21 (3): 592–599. doi:10.1093/humrep/dei400. PMID 16339169.
- Choi, K.; Zhuang, H.; Crain, B.; Doré, S. (2008). "Expression and Localization of Prostaglandin Transporter in Alzheimer Disease Brains and Age-Matched Controls". Journal of Neuroimmunology. 195 (1–2): 81–87. doi:10.1016/j.jneuroim.2008.01.014. PMC 2365511. PMID 18353443.
- Holla, V. R.; Backlund, M. G.; Yang, P.; Newman, R. A.; Dubois, R. N. (2008). "Regulation of Prostaglandin Transporters in Colorectal Neoplasia". Cancer Prevention Research. 1 (2): 93–99. doi:10.1158/1940-6207.CAPR-07-0009. PMID 19138942.
- Chi, Y.; Schuster, V. L. (2010). "The prostaglandin transporter PGT transports PGH2". Biochemical and Biophysical Research Communications. 395 (2): 168–172. doi:10.1016/j.bbrc.2010.03.108. PMID 20346915.
- Breuiller-Fouche, M.; Leroy, M. -J.; Dubois, O.; Reinaud, P.; Chissey, A.; Qi, H.; Germain, G.; Fortier, M. A.; Charpigny, G. (2010). "Differential Expression of the Enzymatic System Controlling Synthesis, Metabolism, and Transport of PGF2 Alpha in Human Fetal Membranes". Biology of Reproduction. 83 (1): 155–162. doi:10.1095/biolreprod.109.080390. PMID 20357271.
- Lu, R.; Kanai, N.; Bao, Y.; Schuster, V. L. (1996). "Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT)". Journal of Clinical Investigation. 98 (5): 1142–1149. doi:10.1172/JCI118897. PMC 507536. PMID 8787677.
- Lu, R.; Schuster, V. L. (1998). "Molecular Cloning of the Gene for the Human Prostaglandin Transporter hPGT: Gene Organization, Promoter Activity, and Chromosomal Localization". Biochemical and Biophysical Research Communications. 246 (3): 805–812. doi:10.1006/bbrc.1998.8715. PMID 9618293.
- Topper, J. N.; Cai, J.; Stavrakis, G.; Anderson, K. R.; Woolf, E. A.; Sampson, B. A.; Schoen, F. J.; Falb, D.; Gimbrone Jr, M. A. (1998). "Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo". Circulation. 98 (22): 2396–2403. doi:10.1161/01.CIR.98.22.2396. PMID 9832484.
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