SLCO2A1

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SLCO2A1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SLCO2A1, MATR1, OATP2A1, PGT, PHOAR2, SLC21A2, solute carrier organic anion transporter family member 2A1
External IDs MGI: 1346021 HomoloGene: 38077 GeneCards: SLCO2A1
Targeted by Drug
dinoprostone[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005630

NM_033314

RefSeq (protein)

NP_005621

NP_201571.2
NP_201571

Location (UCSC) Chr 3: 133.93 – 134.05 Mb Chr 9: 102.99 – 103.1 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier organic anion transporter family, member 2A1 also known as the prostaglandin transporter (PGT) is a protein that in humans is encoded by the SLCO2A1 gene.[4]

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning organic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.[4]

Clinical relevance[edit]

Mutations in this gene have been shown to cause primary hypertrophic osteoarthropathy.[5]

References[edit]

  1. ^ "Drugs that physically interact with Solute carrier organic anion transporter family member 2A1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b "Entrez Gene: Solute carrier organic anion transporter family, member 2A1". Retrieved 2011-12-30. 
  5. ^ Zhang Z, Xia W, He J, Zhang Z, Ke Y, Yue H, Wang C, Zhang H, Gu J, Hu W, Fu W, Hu Y, Li M, Liu Y (January 2012). "Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy". American Journal of Human Genetics. 90 (1): 125–32. doi:10.1016/j.ajhg.2011.11.019. PMID 22197487. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.