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Solute carrier family 17 (vesicular glutamate transporter), member 8
Symbols SLC17A8 ; DFNA25; VGLUT3
External IDs OMIM607557 MGI3039629 HomoloGene13584 IUPHAR: 1009 GeneCards: SLC17A8 Gene
Species Human Mouse
Entrez 246213 216227
Ensembl ENSG00000179520 ENSMUSG00000019935
UniProt Q8NDX2 Q8BFU8
RefSeq (mRNA) NM_001145288 NM_182959
RefSeq (protein) NP_001138760 NP_892004
Location (UCSC) Chr 12:
100.36 – 100.42 Mb
Chr 10:
89.57 – 89.62 Mb
PubMed search [1] [2]

Solute carrier family 17 member 8 (SLC17A8) also known as the vesicular glutamate transporter 3 (VGluT3) is a protein that in humans is encoded by the SLC17A8 gene.[1]


This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft.[1]

Clinical significance[edit]

Mutations in this gene are the cause of autosomal-dominant nonsyndromic deafness type 25 (DFNA25).[2][3]


Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.