SLC17A8

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SLC17A8
Identifiers
Aliases SLC17A8, DFNA25, VGLUT3, solute carrier family 17 member 8
External IDs MGI: 3039629 HomoloGene: 13584 GeneCards: 246213
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_139319
NM_001145288

NM_182959
NM_001310710

RefSeq (protein)

NP_001138760.1
NP_647480.1

NP_892004.1

Location (UCSC) Chr 12: 100.36 – 100.42 Mb Chr 10: 89.57 – 89.62 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 17 member 8 (SLC17A8) also known as the vesicular glutamate transporter 3 (VGluT3) is a protein that in humans is encoded by the SLC17A8 gene.[1]

Function[edit]

This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft.[1]

Clinical significance[edit]

Mutations in this gene are the cause of autosomal-dominant nonsyndromic deafness type 25 (DFNA25).[2][3]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.