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Aliases SLC12A7, KCC4, solute carrier family 12 member 7
External IDs MGI: 1342283 HomoloGene: 21312 GeneCards: SLC12A7
RNA expression pattern
PBB GE SLC12A7 218066 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 1.05 – 1.11 Mb Chr 13: 73.73 – 73.82 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Solute carrier family 12 member 7 is a protein that in humans is encoded by the SLC12A7 gene.[3][4]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mount DB, Mercado A, Song L, Xu J, George AL, Delpire E, Gamba G (June 1999). "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family". The Journal of Biological Chemistry. 274 (23): 16355–62. PMID 10347194. doi:10.1074/jbc.274.23.16355. 
  4. ^ "Entrez Gene: SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7". 

Further reading[edit]

  • Mercado A, Song L, Vazquez N, Mount DB, Gamba G (September 2000). "Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4". The Journal of Biological Chemistry. 275 (39): 30326–34. PMID 10913127. doi:10.1074/jbc.M003112200. 
  • Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (December 2000). "Characterization of long cDNA clones from human adult spleen". DNA Research. 7 (6): 357–66. PMID 11214971. doi:10.1093/dnares/7.6.357. 
  • Boettger T, Hübner CA, Maier H, Rust MB, Beck FX, Jentsch TJ (April 2002). "Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4". Nature. 416 (6883): 874–8. PMID 11976689. doi:10.1038/416874a. 
  • Bräuer M, Frei E, Claes L, Grissmer S, Jäger H (July 2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts". American Journal of Physiology. Cell Physiology. 285 (1): C22–30. PMID 12637262. doi:10.1152/ajpcell.00289.2002. 
  • Karadsheh MF, Byun N, Mount DB, Delpire E (2004). "Localization of the KCC4 potassium-chloride cotransporter in the nervous system". Neuroscience. 123 (2): 381–91. PMID 14698746. doi:10.1016/j.neuroscience.2003.10.004. 
  • Shen MR, Lin AC, Hsu YM, Chang TJ, Tang MJ, Alper SL, Ellory JC, Chou CY (September 2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". The Journal of Biological Chemistry. 279 (38): 40017–25. PMID 15262997. doi:10.1074/jbc.M406706200. 
  • Hsu YM, Chou CY, Chen HH, Lee WY, Chen YF, Lin PW, Alper SL, Ellory JC, Shen MR (March 2007). "IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness". Journal of Cellular Physiology. 210 (3): 626–36. PMID 17133354. doi:10.1002/jcp.20859.