SLC27A2

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SLC27A2
Identifiers
Aliases SLC27A2, ACSVL1, FACVL1, FATP2, HsT17226, VLACS, VLCS, hFACVL1, solute carrier family 27 member 2
External IDs MGI: 1347099 HomoloGene: 37830 GeneCards: 11001
EC number 6.2.1.3
RNA expression pattern
PBB GE SLC27A2 205768 s at tn.png

PBB GE SLC27A2 205769 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003645
NM_001159629

NM_011978

RefSeq (protein)

NP_001153101.1
NP_003636.2

NP_036108.2

Location (UCSC) Chr 15: 50.18 – 50.24 Mb Chr 2: 126.55 – 126.59 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Very long-chain acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A2 gene.[3][4]

The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very long chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wakui K, Aoyama T, Uchiyama A, Hashimoto T, Fukushima Y (Oct 1998). "Assignment of human fatty-acid-coenzyme A ligase, very long-chain 1 gene (FACVL1) to human chromosome band 15q21.2 by fluorescence in situ hybridization". Cytogenet Cell Genet. 81 (3-4): 292–3. doi:10.1159/000015051. PMID 9730624. 
  4. ^ a b "Entrez Gene: SLC27A2 solute carrier family 27 (fatty acid transporter), member 2". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.