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Solute carrier family 27 (fatty acid transporter), member 2
Symbols SLC27A2 ; ACSVL1; FACVL1; FATP2; HsT17226; VLACS; VLCS; hFACVL1
External IDs OMIM603247 MGI1347099 HomoloGene37830 IUPHAR: 1109 ChEMBL: 4326 GeneCards: SLC27A2 Gene
EC number
RNA expression pattern
PBB GE SLC27A2 205769 at tn.png
PBB GE SLC27A2 205768 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11001 26458
Ensembl ENSG00000140284 ENSMUSG00000027359
UniProt O14975 O35488
RefSeq (mRNA) NM_001159629 NM_011978
RefSeq (protein) NP_001153101 NP_036108
Location (UCSC) Chr 15:
50.18 – 50.24 Mb
Chr 2:
126.55 – 126.59 Mb
PubMed search [1] [2]

Very long-chain acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A2 gene.[1][2]

The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very long chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy.[2]

See also[edit]


  1. ^ Wakui K, Aoyama T, Uchiyama A, Hashimoto T, Fukushima Y (Oct 1998). "Assignment of human fatty-acid-coenzyme A ligase, very long-chain 1 gene (FACVL1) to human chromosome band 15q21.2 by fluorescence in situ hybridization". Cytogenet Cell Genet 81 (3-4): 292–3. doi:10.1159/000015051. PMID 9730624. 
  2. ^ a b "Entrez Gene: SLC27A2 solute carrier family 27 (fatty acid transporter), member 2". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.