Chloride potassium symporter
The potassium chloride symporter is a membrane transport protein that is present in the S3-segment of the renal proximal tubule and in the neuron. It functions in renal chloride reabsorption to transport chloride across the basolateral membrane. The concentrations of K+ and Cl− ions are high inside the cell due to the activities of Na+-K+ pump and NKCC cotransporter, respectively. Hence, their net driving force acting on the K/Cl cotransporter favours the exit of both K+ and Cl− from the cell.
They are of solute carrier family 12.
Types of chloride potassium symporter are:
Each is encoded by a separate gene.
The preceding symporters are other types of ion pumps. Member 3, for instance, is the sodium-chloride symporter.
- Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 780
- "Entrez Gene: SLC12A5 solute carrier family 12, (potassium-chloride transporter) member 5". Retrieved 28 August 2013.
|F-, V-, and A-type ATPase (3.A.2)|
|P-type ATPase (3.A.3)|
see also ATPase disorders
see also solute carrier disorders
see also disorders
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