SLC6A15

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SLC6A15
Identifiers
Aliases SLC6A15, NTT73, SBAT1, V7-3, hv7-3, solute carrier family 6 member 15
External IDs MGI: 2143484 HomoloGene: 18163 GeneCards: SLC6A15
Targeted by Drug
loratadine[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146335
NM_018057
NM_182767

NM_001252330
NM_175328

RefSeq (protein)

NP_001139807
NP_060527
NP_877499

NP_001239259.1
NP_780537.1
NP_001239259
NP_780537

Location (UCSC) Chr 12: 84.86 – 84.91 Mb Chr 10: 103.37 – 103.42 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 6 member 15 (SLC6A15) also known as the sodium-dependent neutral amino acid transporter B(0)AT2 (B0AT2)' is a protein that in humans is encoded by the SLC6A15 gene.[4]

Function[edit]

SLC6A15 shows structural characteristics of an Na+ and Cl-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[5]

Clinical relevance[edit]

Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.[6]

References[edit]

  1. ^ "Drugs that physically interact with Solute carrier family 6 member 15 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: solute carrier family 6 (neutral amino acid transporter)". 
  5. ^ Farmer MK, Robbins MJ, Medhurst AD, Campbell DA, Ellington K, Duckworth M, Brown AM, Middlemiss DN, Price GW, Pangalos MN (Dec 2000). "Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family". Genomics. 70 (2): 241–52. doi:10.1006/geno.2000.6387. PMID 11112352. 
  6. ^ Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB (Apr 2011). "The neuronal transporter gene SLC6A15 confers risk to major depression". Neuron. 70 (2): 252–65. doi:10.1016/j.neuron.2011.04.005. PMC 3112053Freely accessible. PMID 21521612. 

Further reading[edit]