Interleukin 20 receptor, beta subunit: Difference between revisions
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Importing Wikidata short description: Protein-coding gene in the species Homo sapiens (shortdescs-in-category) |
Immcarle189 (talk | contribs) Added/fixed introduction section to contain more details about what the subunit is in, what's it involved in, and where it's found. |
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
{{Short description|Protein-coding gene in the species Homo sapiens}} |
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'''Interleukin 20 [[Receptor (biochemistry)|receptor]], beta subunit (IL20R2 or IL20RB)''' is a [[Protein subunit|subunit]] of the [[Interleukin-20 receptor|interleukin-20 receptor and interleukin-22 receptor]]. It is believed to be involved in both pro-inflammatory and anti-inflammatory responses.<ref>{{Cite journal |last=Rutz |first=Sascha |last2=Wang |first2=Xiaoting |last3=Ouyang |first3=Wenjun |date=2014-11-25 |title=The IL-20 subfamily of cytokines — from host defence to tissue homeostasis |url=http://dx.doi.org/10.1038/nri3766 |journal=Nature Reviews Immunology |volume=14 |issue=12 |pages=783–795 |doi=10.1038/nri3766 |issn=1474-1733}}</ref><ref>{{Cite journal |last=Wegenka |first=Ursula Maria |date=2010-10 |title=IL-20: Biological functions mediated through two types of receptor complexes |url=http://dx.doi.org/10.1016/j.cytogfr.2010.08.001 |journal=Cytokine & Growth Factor Reviews |volume=21 |issue=5 |pages=353–363 |doi=10.1016/j.cytogfr.2010.08.001 |issn=1359-6101}}</ref> |
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'''Interleukin-20 receptor beta chain''' is a [[protein]] that in humans is encoded by the ''IL20RB'' [[gene]].<ref name="pmid11163236">{{cite journal |vauthors=Blumberg H, Conklin D, Xu WF, Grossmann A, Brender T, Carollo S, Eagan M, Foster D, Haldeman BA, Hammond A, Haugen H, Jelinek L, Kelly JD, Madden K, Maurer MF, Parrish-Novak J, Prunkard D, Sexson S, Sprecher C, Waggie K, West J, Whitmore TE, Yao L, Kuechle MK, Dale BA, Chandrasekher YA | title = Interleukin 20: discovery, receptor identification, and role in epidermal function | journal = Cell | volume = 104 | issue = 1 | pages = 9–19 |date=Feb 2001 | pmid = 11163236 | doi =10.1016/S0092-8674(01)00187-8 | s2cid = 7460710 | doi-access = free }}</ref><ref name="pmid16703417">{{cite journal |vauthors=Wei CC, Hsu YH, Li HH, Wang YC, Hsieh MY, Chen WY, Hsing CH, Chang MS | title = IL-20: biological functions and clinical implications | journal = J Biomed Sci | volume = 13 | issue = 5 | pages = 601–12 |date=Sep 2006 | pmid = 16703417 | doi = 10.1007/s11373-006-9087-5 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IL20RB interleukin 20 receptor beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53833}}</ref> |
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IL20RB is found in many organ resident effector cells such as [[Keratinocyte|keratinocytes]] at the skin [[epidermis]], [[Osteoclast|osteoclasts]], found in bones, and [[Epithelium|epithelial]] cells of the [[Gastrointestinal tract|intestine]] and [[trachea]]. IL20RB is also found in some [[Immune system|immune]] cells.<ref>{{Cite journal |last=Kragstrup |first=Tue W. |last2=Andersen |first2=Thomas |last3=Heftdal |first3=Line D. |last4=Hvid |first4=Malene |last5=Gerwien |first5=Jens |last6=Sivakumar |first6=Pallavur |last7=Taylor |first7=Peter C. |last8=Senolt |first8=Ladislav |last9=Deleuran |first9=Bent |date=2018-09-25 |title=The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis |url=http://dx.doi.org/10.3389/fimmu.2018.02226 |journal=Frontiers in Immunology |volume=9 |doi=10.3389/fimmu.2018.02226 |issn=1664-3224}}</ref> |
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Revision as of 17:19, 10 March 2023
Interleukin 20 receptor, beta subunit (IL20R2 or IL20RB) is a subunit of the interleukin-20 receptor and interleukin-22 receptor. It is believed to be involved in both pro-inflammatory and anti-inflammatory responses.[5][6]
IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RB is also found in some immune cells.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000174564 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044244 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Rutz, Sascha; Wang, Xiaoting; Ouyang, Wenjun (2014-11-25). "The IL-20 subfamily of cytokines — from host defence to tissue homeostasis". Nature Reviews Immunology. 14 (12): 783–795. doi:10.1038/nri3766. ISSN 1474-1733.
- ^ Wegenka, Ursula Maria (2010-10). "IL-20: Biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews. 21 (5): 353–363. doi:10.1016/j.cytogfr.2010.08.001. ISSN 1359-6101.
{{cite journal}}: Check date values in:|date=(help) - ^ Kragstrup, Tue W.; Andersen, Thomas; Heftdal, Line D.; Hvid, Malene; Gerwien, Jens; Sivakumar, Pallavur; Taylor, Peter C.; Senolt, Ladislav; Deleuran, Bent (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9. doi:10.3389/fimmu.2018.02226. ISSN 1664-3224.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
Further reading
- Dumoutier L, Leemans C, Lejeune D, et al. (2001). "Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types". J. Immunol. 167 (7): 3545–9. doi:10.4049/jimmunol.167.7.3545. PMID 11564763.
- Parrish-Novak J, Xu W, Brender T, et al. (2003). "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions". J. Biol. Chem. 277 (49): 47517–23. doi:10.1074/jbc.M205114200. PMID 12351624.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Pletnev S, Magracheva E, Kozlov S, et al. (2003). "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20". Biochemistry. 42 (43): 12617–24. doi:10.1021/bi0354583. PMID 14580208.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
External links
- Overview of all the structural information available in the PDB for UniProt: Q6UXL0 (Interleukin-20 receptor subunit beta) at the PDBe-KB.
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